Table 4 Genes related to the vascular system and exhibited Semax-induced alteration of expression levels

3h

Cysteine-rich, angiogenic inducer, 61, mRNA.

Cyr61

83476

2.43

1.5E-07

Activating transcription factor 3, mRNA.

Atf3

25389

2.24

3.9E-03

Kruppel-like factor 4 (gut), mRNA.

Klf4

114505

2.23

2.0E-03

A disintegrin-like and metallopeptidse (reprolysin type) with thrombospondin type 1 motif, 1, mRNA.

Adamts1

79252

2.18

5.2E-11

FBJ murine osteosarcoma viral oncogene homolog, mRNA.

Fos

314322

2.11

2.0E-04

Jun B proto-oncogene, mRNA.

Junb

24517

2.07

1.8E-06

Nuclear factor, interleukin 3 regulated, mRNA.

Nfil3

114519

2.03

5.4E-08

Prostaglandin-endoperoxide synthase 2, mRNA.

Ptgs2/Cox2

29527

2.00

8.3E-34

Brain derived neurotrophic factor, mRNA.

Bdnf

24225

1.88

2.0E-04

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5, mRNA.

Smarca5

307766

1.74

2.9E-09

Zinc finger protein 36, mRNA.

Zfp36

79426

1.73

5.5E-03

Early growth response 2, mRNA.

Egr2

114090

1.70

6.6E-03

Dual specificity phosphatase 1, mRNA.

Dusp1

114856

1.67

3.0E-08

Heat shock 27 kDa protein 1, mRNA.

Hspb1

24471

1.63

9.0E-03

Intercellular adhesion molecule 1, mRNA.

Icam1

25464

1.61

9.9E-05

Secretogranin II (chromogranin C), mRNA.

Scg2

24765

1.60

3.6E-04

Relaxin 1, mRNA.

Rln1

25616

1.58

4.0E-03

Amyloid beta (A4) precursor protein, mRNA.

App

54226

0.66

1.9E-03

Mitogen activated protein kinase 10, mRNA.

Mapk10

25272

0.66

2.6E-03

Fibronectin 1, mRNA.

Fn1

25661

0.63

5.1E-04

Catalase, mRNA.

Cat

24248

0.51

2.9E-05

RT1 class II, locus Ba, mRNA.

RT1-Ba

309621

0.51

3.1E-07

CD74 antigen (invariant polpypeptide of MHC class II antigen-associated), mRNA.

Cd74

25599

0.50

1.6E-09

RT1 class Ia, locus A1, mRNA.

RT1-A1

24973

0.50

7.6E-10

24h

Genes related to the vascular system (12 genes):

Chemokine (C-X-C motif) ligand 9, mRNA.

Cxcl9

246759

2.42

1.8E-14

Chemokine (C-X-C motif) ligand 10, mRNA.

Cxcl10

245920

2.32

1.9E-03

RT1 class II, locus Ba, mRNA.

RT1-Ba

309621

2.28

1.5E-15

Chemokine (C-C motif) ligand 5, mRNA.

Ccl5

81780

1.98

6.5E-05

RT1 class Ia, locus A1, mRNA.

RT1-A1

24973

1.94

2.8E-11

Chemokine (C-C motif) ligand 7, mRNA.

Ccl7

287561

1.78

8.3E-04

Nephroblastoma overexpressed gene, mRNA.

Nov

81526

1.64

3.2E-06

CD74 antigen (invariant polpypeptide of MHC class II antigen-associated), mRNA.

Cd74

25599

1.63

5.3E-06

Secreted phosphoprotein 1, mRNA.

Spp1

25353

1.58

3.4E-06

Plasminogen activator, tissue, mRNA.

Plat

25692

0.65

1.1E-07

Podoplanin, mRNA.

Pdpn

54320

0.63

5.3E-10

A disintegrin-like and metallopeptidse (reprolysin type) with thrombospondin type 1 motif, 1, mRNA.

Adamts1

79252

0.56

7.5E-09