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Table 2 Genes of the virulence condition synergy group

From: Transcriptome analysis identifies Bacillus anthracis genes that respond to CO2through an AtxA-dependent mechanism

Locus tag Gene name Accession number (NCBI) Adjusted P-Value Fold-change Length of predicted protein (AA) Putative function
pXO1_0122   YP_016453.2 0.0074 5.0 158 Hypothetical protein
  sRNA-1   < 0.0001 338.5   Unknown
pXO1_0123   YP_016454.2 0.0008 68.2 34 Hypothetical protein
pXO1_0124 bslA YP_016455.2 < 0.0001 192.1 652 Adhesin; virulence factor
pXO1_0125   YP_016456.2 < 0.0001 42.1 280 PAP2 family phosphatase
pXO1_0137   YP_016468.2 0.0008 63.7 151 Hypothetical protein
pXO1_0142 cya YP_016473.2 0.0065 4.1 800 Edema toxin; virulence factor
  sRNA-2   < 0.0001 332.1   Unknown
pXO1_0151   YP_016482.2 < 0.0001 141.8 44 Hypothetical protein
pXO1_0153   YP_016484.2 < 0.0001 69.1 76 Hypothetical protein
pXO1_0164 pagA YP_016495.2 < 0.0001 130.9 764 Protective antigen; virulence factor
pXO1_0165   YP_016496.2 < 0.0001 84.2 34 Hypothetical protein
pXO1_0166 pagR YP_016497.2 < 0.0001 126.2 99 Transcriptional regulator
pXO1_0171   YP_016502.2 < 0.0001 17.7 68 Hypothetical protein
pXO1_0172 lef YP_016503.2 0.0024 30.9 809 Lethal toxin; virulence factor
GBAA0793   YP_017427.1 0.0002 10.9 436 Phosphotransferase system
GBAA0795   YP_052611.1 <0.0001 9.7 361 DUF871 superfamily
GBAA2301   YP_018949.1 <0.0001 7.5 90 YokU superfamily
  1. This table lists genes whose expression patterns are best explained by a synergistic relationship between the presence of AtxA and CO2. P-values were determined using a likelihood ratio test of the interaction between genotype and environment. Fold-change refers to the ratio of the counts mapping to that gene in conditions of WT/CO2 over ΔAtxA/air. Gene functions listed are those determined by validated experiments in B. anthracis or the primary conserved domain is indicated if validated data are lacking. In the absence of conserved domains, the function is listed as a “Hypothetical protein”.