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Table 2 Association of TF motifs with Nfib targets

From: An overlapping set of genes is regulated by both NFIB and the glucocorticoid receptor during lung maturation

Motif Gene FC p a c t p r e p MAS
NFIA_full Nfia 2.27 <10-5 0.31 5.50
NFIB_full Nfib *2.75 <10-5 0.27 5.12
NFIX_full Nfix - <10-4 0.26 4.67
Meis3_DBD_2 Meis3 NA <10-4 0.44 4.13
MEIS3_DBD_2 Meis3 NA <10-4 0.44 4.03
Meis2_DBD_2 Meis2 1.57 0.0001 0.53 3.98
SNAI2_DBD Snai2 1.72 0.0002 0.86 3.78
Rxra_DBD Rxra - 0.0004 0.54 3.49
EBF1_full Ebf1 - 0.0004 0.46 3.49
Rxrb_DBD Rxrb NA 0.0004 0.69 3.49
NR2F6_DBD_2 Nr2f6 - 0.0004 0.75 3.46
RXRA_DBD Rxra - 0.0006 0.62 3.22
NR2F1_DBD Nr2f1 1.83 0.0007 0.74 3.18
RXRB_DBD Rxrb NA 0.0007 0.41 3.16
Pknox2_DBD Pknox2 - 0.0009 0.41 3.05
TFAP4_full Tfap4 NA 0.0010 0.24 3.02
PKNOX2_DBD Pknox2 - 0.0010 0.60 3.00
RXRG_DBD Rxrg NA 0.0011 0.49 2.96
NR2C2_DBD Nr2c2 - 0.0012 0.65 2.93
Nfib_MEME Nfib *2.75 0.0012 0.34 2.92
  1. The table shows the TF motif name (motif), associated gene name (gene), expression fold-change (FC) of the gene, the (unadjusted) motif enrichment p-value in the activated set of genes (p a c t ), the (unadjusted) motif enrichment p-value in the repressed set of genes (p r e p ), and the motif association score (MAS). Rank is based on the magnitude of the MAS, β€œNA” indicates that no expression data is available for the TF gene and β€œ-” in the FC column indicates that expression change is not significant (p-value >0.05). Motif names all in uppercase are derived from human TFs, others are from mouse TFs. *Although Nfib expression increases in the Nfib-KO, no functional protein is produced.