Characterization of the transcriptome and temperature-induced differential gene expression in QPX, the thraustochytrid parasite of hard clams

Table 4 Gene Ontology terms enriched in response to temperature changes (Fisher’s exact test with multiple testing correction of FDR < 0.05, Benjamini and Hochberg)

GO term ID	Gene ontology term description	GO type	FDR	p-value	% in DE group^a	% on array^b	Fold enrich^c
Up-regulated at 27°C
GO:0006548	Histidine catabolic process	P	2.9E-02	2.8E-05	5.4	0.0	151
GO:0016829	Lyase activity	F	2.5E-02	8.0E-06	19.6	3.7	5
Down-regulated at 27°C
GO:0019915	Lipid storage	P	1.8E-02	2.2E-05	3.7	0.0	104
GO:0005840	Ribosome	C	2.9E-02	5.7E-05	11.1	2.0	6
GO:0003735	Structural constituent of ribosome	F	1.8E-02	2.9E-05	11.1	1.8	6
Up-regulated at 23°C
GO:0006081	Cellular aldehyde metabolic process	P	2.5E-02	3.2E-05	3.5	0.1	49
GO:0003755	Peptidyl-prolyl cis-trans isomerase activity	F	1.3E-02	9.7E-06	4.4	0.1	30
GO:0000502	proteasome complex	C	1.3E-02	1.2E-05	5.3	0.3	16
Down-regulated at 10°C
GO:0006548	Histidine catabolic process	P	8.1E-03	1.0E-05	2.4	0.0	69
GO:0008233	Peptidase activity	F	4.9E-02	1.7E-04	11.0	3.9	3
GO:0016829	Lyase activity	F	4.9E-02	1.9E-04	10.4	3.6	3
GO:0006081	Cellular aldehyde metabolic process	P	4.9E-02	1.4E-04	2.4	0.1	33
GO:0016616	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	F	2.7E-02	4.3E-05	6.1	1.1	6

^aPercent of sequences with that gene ontology term in the differentially expressed gene group.
^bPercent of sequences with that gene ontology term on the whole array.
^cFold enrichment: Fold increase of the GO term in the differentially expressed gene group.

ISSN: 1471-2164