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Table 3 Pathway analysis of biomarkers that distinguish 14 class compounds

From: Identification of biomarkers that distinguish chemical contaminants based on gene expression profiles

Ingenuity canonical pathways -log (p-value) Ratio Molecules
Mitotic roles of polo-like kinase 11.6 1.45E-01 KIF23, CCNB1, ESPL1, CDC20, PTTG1, PRC1, CCNB2, PLK1, CDC2
Cell Cycle: G2/M DNA damage checkpoint regulation 6.17 1.16E-01 CCNB1, TOP2A, CCNB2, PLK1, CDC2
ATM signaling 4.16 7.55E-02 RAD51, CCNB1, CCNB2, CDC2
Nicotinate and nicotinamide metabolism 3.03 2.94E-02 NEK2, PLK1, TTK, CDC2
Inositol phosphate metabolism 2.57 2.27E-02 NEK2, PLK1, TTK, CDC2
Sonic hedgehog signaling 2.15 6.06E-02 CCNB1, CDC2
Pancreatic adenocarcinoma signaling 2 2.59E-02 RAD51, CCNE1, BIRC5
Hereditary breast cancer signaling 1.85 2.33E-02 RAD51, CCNB1, CDC2
Role of BRCA1 in DNA damage response 1.62 3.28E-02 RAD51, PLK1