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Figure 1 | BMC Genomics

Figure 1

From: Implications of human genome structural heterogeneity: functionally related genes tend to reside in organizationally similar genomic regions

Figure 1

Genes provided the GO enrichment of four organizational pattern clusters, which showed the most significant GO enrichments. L2-a cluster (94 out of 392 genes associated with the enriched GO terms) marked by black labels; L2-h cluster 29 out of 126 genes marked by blue labels; H1-i cluster 24 out of 326 genes marked by green labels; H2-a cluster 50 out of 606 genes marked by red labels. Note that different chromosomal regions are shown in the figure in varying scales in order to enable accurate indication of corresponding gene(s) residence. List of enriched GO terms (Benjamini p-values of the GO term enrichments are shown in brackets): (a1) organelle envelope (0.001174); (a2) mitochondrion (0.000760); (a3) membrane-enclosed lumen (0.002300); (a4) ribonucleoprotein complex (0.002055); (b1) G-protein coupled receptor protein signaling pathway (0.002585); (b2) sensory perception of smell (0.003231); (b3) cell surface receptor linked signal transduction (0.033179); (c1) keratinocyte differentiation (4.07 × 10−9); (c2) epithelium development (6.78 × 10−7); (c3) epithelial cell differentiation (2.83 × 10−9); (c4) ectoderm development (4.55 × 10−5); (d1) anterior/posterior pattern formation (1.9 × 10−10); (d2) pattern specification process (2.0 × 10−10); (d3) regionalization (1.9 × 10−10); (d4) skeletal system development (9.7 × 10−10); (d5) embryonic morphogenesis (0.000293).

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