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Table 1 Genes differentially expressed in Paracoccidioides in response to treatment with itraconazole

From: Transcriptional profile of Paracoccidioides spp. in response to itraconazole

Functional category

Gene product

Best hit/Paracoccidioides genome locus

e-value

Number of occurrences a

    

1 h

2 h

Metabolism/Energy

3-deoxy-7-phosphoheptulonate synthase (DAHP)

PAAG_03237

9.2e-29

+2

 

Cysteine desulfurase (CYSD)

PAAG_05850

2.2e-58

+22

 

Betaine aldehyde dehydrogenase (BADH)

PAAG_05392

2.1e-19

+2

 

NADP-specific glutamate dehydrogenase (GDH)

PAAG_07689

1.6e-26

+1

 

NAD dependent epimerase dehydratase (EDH)

PAAG_05580

1.6e-30

+1

 

Succinyl 3-ketoacid-coenzime A transferase (SCOT)

PAAG_05093

2.6e-17

+1

 

Ribulose-phosphate 3-epimerase (RP3E)

PAAG_01632

6.5e-42

-17

 

Aconitase (ACO)

PAAG_05328

5.8e-18

-2

 

D-amino-acid oxidase (DAAO)

PAAG_02361

2.4e-38

-3

 

Er-associated proteolytic system protein (ERAD)

PAAG_04633

8.6e-40

-4

 

Isovaleryl-CoA dehydrogenase (IVD)

PAAG_06830

1.0e-23

+4

 

Acyl-CoA dehydrogenase (ADH)

PAAG_05211

1.0e-30

+1

 

Acyl-CoA dehydrogenase (ADH)

PAAG_01222

2.1e-19

-8

 

Hormone-sensitive lipase (LIPE)

PAAG_06218

7.6e-37

+1

 

Pyruvate kinase (PK)

PAAG_06380

3.1e-31

+1

 

Aldehyde dehydrogenase (ALDH)

PAAG_05249

1.0e-44

-4

 

Glutamine amidotranferase subunit pdxT (GLAT)

PAAG_07505

1.3e-23

-5

 

ATP synthase f0 subunit 9 (ATPS9)

PAAG_12009

3.0e-17

 

+22

Short chain dehydrogenase (DHS-14)

PAAG_04787

3.2e-48

+1

 

Transcription

Transcription factor (STEA)

PAAG_00406

8.4e-50

+3

 

Isoform cra_b

PAAG_05467

3.2e-15

+1

 

Fator transcrição tipo CCCH

PAAG_02735

4.2e-27

+1

 

Pirin (PIR)

PAAG_04726

2.5e-52

+7

+47

RING finger protein (RNF)

PAAG_06129

1.5e-18

+2

 

Apses transcription (APSES)

PAAG_02379

1.6e-30

+1

 

mRNA-nucleus export ATPase

PAAG_04548

4.0e-45

-27

 

C6 transcription factor (CTFIB)

PAAG_01359

4.5e-65

-12

 

Cell rescue, Defense and Virulence

 

Survival factor1 (SVF1)

PAAG_02425

4.7e-36

+1

 

Gluthatione S-transferase (GST)

PAAG_03931

1.0e-33

+1

 

Vanadate resistence protein

PAAG_03940

9.4e-54

+2

 

Heat shock protein (STI1)

PAAG_06811

2.2e-24

+2

 

Heat shock protein (HSP10)

PAAG_05142

6.5e-32

+1

+2

Heat shock protein (HSP30)

PAAG_00871

5.4e-52

-26

-33

Heat shock protein (HSP70)

PAAG_08003

4.4e-40

 

+3

Heat shock protein (HSP60)

PAAG_08059

4.3e-55

 

-12

Protein synthesis and biogenesis

 

ATP-dependent RNA helicase (ELF4A)

PAAG_00689

1.3e-24

+7

 

Serine threonine-protein kinase (SRK1)

PAAG_06726

7.6e-66

-2

 

40S ribosomal protein S4 (RPS4)

PAAG_03816

7.3e-37

 

+2

Protein fate (folding, modification, destination)

 

Ubiquitin-protein ligase (UBI)

PAAG_02632

3.7e-11

+2

 

WD repeat containing protein (WDR)

PAAG_00103

1.0e-25

+1

 

Ubiquitin thioesterase (OTU1)

PAAG_08841

1.0e-32

-5

 

Ubiquitin fusion degradation protein (UFD)

PAAG_01475

1.0e-62

 

+1

Proteasome component (PREP6)

PAAG_07802

6.1e-5

+1

 

Cellular transport, transport facilities and transport routes

 

Tetracycline resistance protein (TETA)

PAAG_01353

1.0e-56

+13

 

Mfs transporter (MFS)

PAAG_02191

7.3e-56

+9

 

Nucleoporin (SONB)

PAAG_02655

1.1e-36

+1

 

Voltage-gated Ca2+ alpha subunit (CAV)

PAAG_01353

9.9e-15

+1

 

Sodium-dependent phosphate transporter (SPIT)

PAAG_03892

1.5e-11

+1

 

Zinc finger membrane protein (DHHC)

PAAG_06616

6.6e-53

-4

 

autophagy regulatory protein

PAAG_04970

2.6e-33

-2

 

GPR1/FUN34/YAAH family protein

PAAG_08587

1.2e-47

-13

-5

Carnitine/acyl carnitine carrier (CAR)

PAAG_03452

1.7e-30

-18

-89

General secretion pathway protein.

PAAG_05009

2.7e-60

-10

 

Family integral membrane protein (IMP)

PAAG_03183

4.1e-50

 

+1

Hemolisyn-iii channel protein (HLYiii)

PAAG_01871

6.0e-34

 

+3

Integral membrane MPV17/PMP22

PAAG_02868

6.6e-37

 

-2

Vesicular fusion protein (SEC17)

PAAG_06233

2.8e-77

 

-1

Biogenesis of Cellular Components (cell wall/membrane)

 

Chitin synthase regulator 2 (CHSr)

PAAG_04860

2.0e-17

+3

 

Oxysterol-binding protein (OSBP)

PAAG_06807

3.6e-45

 

+6

Diacylglycerol o-acyltransferase (DGAT)

PAAG_07527

1.4e-64

+1

 

Phosphatidyl synthase (PHS)

PAAG_03571

6.5e-34

+1

 

Cellular communication/Signal transduction mechanism

 

FluG Domain-containing protein

PAAG_05486

1.0e-53

+1

 

Leucine –rich repeat Igi member 4 (LGI4)

PAAG_00833

1.0e-25

+1

 

Conserved Lysine protein (LYS)

PAAG_03092

6.2e-43

+2

 

Unclassified protein

Conserved hypothetical protein

PAAG_02735

1.3e-39

+2

 

Conserved hypothetical protein

PAAG_01353

1.3e-18

+6

 

Conserved hypothetical protein

PAAG_07364

5.8e-30

+4

 

Conserved hypothetical protein

PAAG_00520

3.9e-27

+3

 

Conserved hypothetical protein

PAAG_02379

1.5e-19

+2

 

Conserved hypothetical protein

PAAG_02210

1.8e-37

+6

 

Conserved hypothetical protein

PAAG_02236

1.0e-15

+1

 

Conserved hypothetical protein

PAAG_03559

4.8e-47

+1

 

Conserved hypothetical protein

PAAG_03596

4.4e-83

+3

 

Conserved hypothetical protein

PAAG_08759

1.5e-63

+2

 

Conserved hypothetical protein

PAAG_07907

1.0e-42

+2

 

Conserved hypothetical protein

PAAG_04000

1.0e-44

-4

 

Conserved hypothetical protein

PAAG_06816

1.7e-8

 

-2

Conserved hypothetical protein

PABG_06807

1.0e-51

 

-6

Conserved hypothetical protein

PAAG_01871

1.0e-51

 

-2

Conserved hypothetical protein

PAAG_07034

3.4e-33

+2

 

Conserved hypothetical protein

PADG_04444

6.7e-17

 

+2

Hypothetical protein

PAAG_02259

1.0e-18

-3

 

Hypothetical protein

PAAG_02991

4.9e-37

+1

 
 

Domain-containing protein (DUF1688)

PAAG_04000

7.5e-17

+2

 
  1. aOccurrences are expressed as the fold change relative to the value for the nontreated control; +, induction; -, repression.