Novelty compared to 1000 genomes project. We compared the number of nonreference variants in the South African KhoeSan [SSAN] with (A) 1000 Genomes Yoruba samples [YRI], (B) eastern African Luhya [LWK], and (C) Namibian San from HGDP and African-Americans [ASW]. Sites that were included in this analysis required the presence of genotype information for at least 95% of the individuals in the joint dataset. The exome data from ASW and LWK was derived from 1000 Genomes Project, Phase 1 – March 17, 2012 release, from which 13 individuals were randomly sampled. The Venn diagram illustrates the number of shared and unique nonreference variants among populations. The Vennerable package in R was utilized for plotting purposes.