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Table 1 Association with T1D tested in the joint copy number group KIR3DS1 - KIR3DL1 (a), and in the marginal KIR3DL1 (b) and KIR3DS1 (c) copy number groups

From: A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples

a)

qPCR

SNP

KIR3DS1-KIR3DL1

Case:control

Total

OR

95% CI

p-value

Case:control

Total

OR

95% CI

p-value

0-2

444:446

890

1.00

  

4094:3222

7316

1

  

1-1

229:207

436

1.11

0.88-1.40

0.3673

2050:1628

3678

0.99

0.92-1.07

0.8349

2-0

26:28

54

0.92

0.52-1.61

0.7713

229:225

454

0.79

0.65-0.96

0.0193

2-1

15:16

31

0.94

0.46-1.93

0.8695

121:101

222

0.92

0.7-1.2

0.5246

1-2

13:14

27

0.93

0.43-2.01

0.8587

98:74

172

1.04

0.77-1.42

0.7822

0-1

13:11

24

1.19

0.53-2.68

0.6794

116:77

193

1.19

0.89-1.59

0.2535

1-0

4:3

7

1.34

0.30-6.02

0.7031

25:21

46

0.94

0.52-1.68

0.8255

3-0

3:2

5

1.52

0.27-8.62

0.6369

11:14

25

0.74

0.3-1.82

0.518

Overall

747:727

1474

  

0.9842

6744:5362

12106

  

0.3552

b)

qPCR

SNP

KIR3DL1

Case:control

Total

OR

95% CI

p-value

Case:control

Total

OR

95% CI

p-value

2

457:460

917

1.00

  

4192:3296

7488

1

  

1

257:234

491

1.11

0.89-1.38

0.3702

2287:1806

4093

0.99

0.92-1.07

0.8883

0

33:33

66

1.01

0.61-1.66

0.9795

265:260

525

0.8

0.67-0.96

0.0151

Overall

747:727

1474

  

0.6651

6744:5362

12106

  

0.0506

c)

qPCR

SNP

KIR3DS1

Case:control

Total

OR

95% CI

p-value

Case:control

Total

OR

95% CI

p-value

0

457:457

914

1.00

  

4210:3299

7509

1

  

1

246:224

470

1.10

0.88-1.37

0.4096

2173:1723

3896

0.99

0.91-1.07

0.7785

2

41:44

85

0.94

0.60-1.47

0.7787

350:326

676

0.83

0.71-0.97

0.0212

3

3:2

5

1.24

0.21-7.28

0.8084

11:14

25

0.74

0.3-1.82

0.5119

Overall

747:727

1474

  

0.8044

6744:5362

12106

  

0.1494

  1. No evidence of a significant, joint or marginal, effect was detected in the qPCR dataset, 747 cases and 727 controls, nor in the SNP dataset, 6744 cases and 5362 controls. Case-control counts shown are derived from the most likely copy number assignment across the ten multiply imputed qPCR and SNP datasets. Statistical inference for association is derived from the multiply imputed datasets using the R mitools package [13]. The last row of each table contains the pooled p-value for each association test using the R mice package [14].
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BMC Genomics

ISSN: 1471-2164

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