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Figure 5 | BMC Genomics

Figure 5

From: Integrative analyses of genetic variation, epigenetic regulation, and the transcriptome to elucidate the biology of platinum sensitivity

Figure 5

Functional validation of ABCD2 and miR-30d. A) Increase in cisplatin-induced apoptosis 24 hours after transfection with 40nM ABCD2 siRNA as compared to scrambled control siRNA (p = 0.013). B) Increased miR-30d expression 24 hours after transfection with 40nM miR-30d mimic (normalized to RNU6 housekeeping control) compared to scrambled control siRNA (p = 0.001). C) Decreased ABCD2 expression 24 hours after transfection with miR-30d mimic (normalized to B2M housekeeping control) compared to scramble control siRNA (p = 0.047); data not shown for ABCD2 siRNA as remaining amount of ABCD2 mRNA was no longer quantifiable by qPCR 24 hours after transfection.

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BMC Genomics

ISSN: 1471-2164

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