Table 1 Pyramid analysis summary results for carboplatin- and cisplatin-DSP in HapMap YRI samples

Stage 1

DSP – mRNA expression correlation

<0.05

829 genes (832 TCs)

913 genes (918 TCs)

Stage 2

DSP – miRNA expression correlation

<0.05

34 miRNA

20 miRNAs

Stage 3

Inverse correlation between miRNA and mRNA expression

<0.0001

141 genes

18 genes

27 miRNAs

7 miRNAs

Stage 4

SNP-mRNA association

≤0.0001

51777 SNPs

9416 SNPs

141 genes

17 genes

Stage 5

SNP-miRNA association

<0.05

38289 SNPs

5437 SNPs

27 miRNAs

7 miRNAs

Stage 6

SNP-DSP association

≤0.0001

9 SNPs

2 SNPs

16 genes

2 genes

19 miRNAs

5 miRNAs

Final assembly

5 SNPs

1 SNP

15 genes

1 gene

10 miRNAs

1 miRNA