Figure 1From: MKL1/2 and ELK4 co-regulate distinct serum response factor (SRF) transcription programs in macrophagesSRF is required for macrophage function in response to zymosan stimulation. (A) Gene ontology analysis for biological process annotations of downregulated and upregulated SRF dependent genes after zymosan treatment for 1 h. (B) mRNA expression profiles of the indicated representative SRF dependent genes were analyzed by Q-PCR. Thioglycollate-elicited macrophages were transfected with nonspecific (NS) or specific siRNAs for SRF and treated with or without zymosan for 1 h. **p < 0.01 vs. NS; *p < 0.05 vs. NS. Target gene expression is represented as the average fold change compared to NS siRNA transfected samples of at least three independent experiments. Error bars represent standard deviations.Back to article page