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Figure 1 | BMC Genomics

Figure 1

From: MKL1/2 and ELK4 co-regulate distinct serum response factor (SRF) transcription programs in macrophages

Figure 1

SRF is required for macrophage function in response to zymosan stimulation. (A) Gene ontology analysis for biological process annotations of downregulated and upregulated SRF dependent genes after zymosan treatment for 1 h. (B) mRNA expression profiles of the indicated representative SRF dependent genes were analyzed by Q-PCR. Thioglycollate-elicited macrophages were transfected with nonspecific (NS) or specific siRNAs for SRF and treated with or without zymosan for 1 h. **p < 0.01 vs. NS; *p < 0.05 vs. NS. Target gene expression is represented as the average fold change compared to NS siRNA transfected samples of at least three independent experiments. Error bars represent standard deviations.

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