Table 2 Up-regulated genes and functional group allocations

Differentiation

Leptin

LEP

74.3

Early Growth Response 2

EGR2

6.78

Inhibin, beta B

INHBB

6.25

Interleukin 11

IL11

5.5

Growth differentiation factor 6

GDF6

5.29

Hemopoietic cell kinase

HCK

4.82

Podoplanin

PDPN

3.65

Ephrin-A3

EFNA3

3.65

Semaphorin A7

SEMA7

2.70

Activin A receptor type IIA

ACVR2A

2.70

Matrix metalloproteinase 11

MMP11

2.52

Aggrecan

ACAN

2.50

Sparc/osteonectin (testican)

SPOCK1

2.2

Frizzled homologue-8

FZD8

3.2

Secreted frizzled related protein 4

SFRP4

2.3

Cadherin 11, type 2 (osteoblast)

CDH11

2.0

Survival/Apoptosis

Transient receptor potential cation channel

TRPM7

6.63

Interleukin 11

IL11

5.5

Metallothionein 3

MT3

4.80

Stanniocalcin 1

STC1

4.8

Regucalcin

RGN

4.04

Vascular endothelial growth factor A

VEGFA

3.56

RAS p21 protein activator 1

RASA1

2.92

Immediate Early Response 3

IER3

2.52

Proliferation/Survival

Insulin-like growth factor binding protein 1

IGFBP1

8.93

Insulin-like growth factor binding protein 3

IGFBP3

3.1

Insulin-like growth factor binding protein 5

IGFBP5

3.1

Interleukin 11

IL11

5.5

Placental Growth Factor

PGF

3.28

Transcription elongation factor A3

TCEA3

2.82

Hepatocyte growth factor receptor

MET

2.70

Heparin-binding EGF-like GF

HBEGF

2.64

Jun B oncogene

JUNB

3.07

c-Jun oncogene

JUN

2.66

Inhibin, beta B

INHBB

6.25

Growth differentiation factor 6

GDF6

5.29

Inhibitor of growth family member 3

ING3

3.53

ECM migration/adhesion/cytoskeleton

Early growth response 2

EGR2

6.78

Interleukin 11

IL11

5.5

Activated leukocyte cell adhesion molecule

ALCAM

2.89

Junctional adhesion molecule 2

JAM2

3.10

Semaphorin 5A

SEMA5A

4.02

Connective tissue growth factor

CTGF

2.40

Protein tyrosine phosphatase, receptor type, F

PTPRF

2.66

Signal-induced proliferation-associated 1 like 1

SIPA1L1

4.0

Intergrins alpha- 1, 3, 5, 6, 7

ITGA

>2.2

Integrin beta-1

ITGB

2.1

Intermediate filament

Periplakin

PPL

7.88

Desmoplakin

DSP

3.86

Keratin 16

KRT16

6.39

Keratin 14

KRT14

4.04

Keratin 20

KRT20

4.40

Keratin 19

KRT19

3.5

Keratin 15

KRT15

3.35

Keratin 13

KRT13

3.37

Keratin 24

KRT24

3.09

Keratin 17

KRT17

2.70

Keratin 12

KRT12

2.60

Mucin 1

MUC1

2.23

KIAA1199

KIAA1199

5.2

RAS p21 protein activator

RASA1

2.92

Microtubule-associated protein 1B

MAO1B

2.70

Microtubule-actin cross-linking factor 1

MACF1

2.4

Lysyl oxidase-like 4

LOX4

6.5

Lysyl oxidase-like 2

LOX2

2.5

Angiogenesis

Leptin

LEP

74.3

Stanniocalcin 1

STC1

4.70

Vascular endothelial growth factor A

VEGFA

4.61

Placental growth factor

PGF

3.28

Hepatocyte growth factor receptor

MET

2.70

PDGF receptor B

PDGFRB

2.1

PDGF receptor A

PDGFRA

2.0

Angiopoietin-like 4

ANGPTL4

2.80

Serpin peptidase inhibitor member 1

SERPINE1

4.92

Serpin peptidase inhibitor member 2

SERPINE2

2.4

Tissue plasminogen activator

PLAT

2.3

Endothelial tyrosine kinase, Ang 1 receptor

TEK

5.16

Lysyl oxidase-like 4

LOX4

6.5

Desmoplakin

DSP

3.86

Noggin

NOG

3.91

Glucose Transport

Glucose transporter member 1

SLC2A1

2.01

Glucose transporter member 3

SLC2A3

2.11

Glucose/fructose transporter member 5

SLC2A5

2.0

Glucose transporter, member 14

SLC2A14

2.88