Table 3 Down-regulated genes and functional group allocations
Class | Gene description | Gene symbol | HX/NX |
|---|---|---|---|
Antioxidant | |||
|  | NAD(P)H dehydrogenase, Quinone 1 | NQO1 | −5.63 |
Aldo-Keto Reductase 1C1 | AKR1C1 | −2.71 | |
Aldo-Keto Reductase 1C2 | AKR1C2 | −2.61 | |
Aldo-Keto Reductase 1C3 | AKR1C3 | −2.60 | |
Aldo-Keto Reductase 1C4 | AKR1C4 | −4.28 | |
Aldo-Keto Reductase1D1 | AKR1D1 | −3.04 | |
Aldo-Keto Reductase 1B10 | AKR1B10 | −3.07 | |
Aldo-Keto Reductase 1B15 | AKR1B15 | −2.10 | |
Glucose 6 phosphate DH | G6PDH | −2.00 | |
Thioredoxin reductase | TXNRD1 | −3.77 | |
Proliferation/growth associated | |||
|  | Insulin-like growth factor 1 | IGF-1 | −3.2 |
PI3-kinase regulatory subunit 2 | PIK3R2 | −2.9 | |
Platelet derived growth factor receptor-like | PDGFRL | −2.85 | |
Fibroblast growth factor 7 | FGF7 | −2.1 | |
Cell cycle arrest checkpoint | RAD9B | −4.4 | |
Mediator of DNA damage checkpoint 1 | MDC1 | −3.39 | |
Helicase (DNA) B | HELB | −4.4 | |
Inhibitor of DNA binding 1 | ID1 | −3.26 | |
Inhibitor of DNA binding 2 | ID2 | −3.0 | |
Inhibitor of DNA binding 4 | ID4 | −3.0 | |
TNF superfamily, member 14 | TNFSF14 | −2.22 | |
Migration-associated | |||
|  | Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | PREX1 | −2.23 |
Coronin 7 | CORO7 | −5.10 | |
Formin homology 2 domain containing 1 | FHOD1 | −2.15 | |
Actin filament associated protein 1 like 2 | AFPAP1L2 | −3.3 | |
Palmdelphin | PALMD | −2.8 | |
Tubulin, alpha 3D | TUBA3D | −3.9 | |
Glucose metabolism | |||
|  | Glucose 6 phosphate DH | G6PDH | −2.00 |
Pyruvate dehydrogenase (liver RBC) | PKLR | −2.61 | |
Phosphoglycerate mutase 2 | PGAM2 | −3.00 | |
Phosphoglycerate mutase 5 | PGAM5 | −2.27 | |
Phosphogluconate dehydrogenase | PGD | −2.55 | |
Glucose transporter, member 4 | SLC2A4 | −2.7 | |
Glucose transporter, member 8 | SLC2A8 | −2.5 | |
Glucose/fructose transporter, member 11 | SLC2A11 | −2.24 | |
Muscle/myogenesis/structural | |||
|  | Actin alpha-1 (Sk) | ACTA1 | −4.33 |
Actin gamma-2 (SM) | ACTG2 | −5.83 | |
Fer-1-like 5 (myotube formation) | FER1L5 | −5.30 | |
Tripartite motif containing 16-like | TRIM16L | −4.95 | |
Myosin heavy chain 2 | MYH2 | −4.0 | |
Myosin heavy chain 7 | MYH7 | −3.0 | |
Troponin T type 2 (cardiac) | TNNT2 | −2.8 | |
ATPase calcium channel (cardiac) | ATP2A1 | −2.94 | |
Myosin binding protein B (fast) | MYBPC2 | −2.79 | |
Miscellaneous | |||
|  | Lysine acetyl transferase 2A | KAT2A | −3.45 |
Galactosidase beta-1-like (senescence) | GLB1L3 | −3.0 | |
Eukaryotic translation initiating factor 2B subunit gamma 3 | EIF2B3 | −2.6 | |
Eukaryotic translation elongating factor 1 epsilon 1 | EEF1E1 | −2.67 | |
Osteocrin | OSTN | −2.3 | |
Elongation factor RNA Pol II, 2 | ELL2 | −2.0 | |
Telomerase associated protein-1 | TEP1 | −2.67 | |
Death associated protein kinase 2 | DK2 | −2.4 | |
Protein kinase C delta | PRKCD | −3.37 | |
Interleukin-8 | IL8 | −3.05 | |
Interleukin-19 | IL19 | −2.61 | |
Interleukin-27 | IL27 | −3.30 | |
Interleukin-28A | IL28A | −2.24 | |
Chemokine (C-C motif) ligand 2 | CCL2 | −3.19 | |