Figure 1

PTR comb iner workflow scheme. PTRcombiner is composed of two main methodological parts. The first, called “Mining combinatorial features” (orange panel), identifies groups (clusters) of regulatory elements (trans-factors) that act on common mRNAs. The second, called “Analyzing combinatorial features” (blue panels), explores the identified clusters to evaluate their biological characteristics in terms of commonly regulated mRNAs, Gene Ontology enrichments, and compatibility of binding sites among trans-factors belonging to the same cluster.