Analyzing combinatorial features, step 1: biological annotation of the trans-factor clusters. The number of HGNC genes targeted by the top five ranking clusters that included either recurrent trans-factors (A) or sporadic trans-factors (B) are displayed. The Jaccard similarities among the top five ranking clusters that included recurrent trans-factors (C) or sporadic trans-factors (D) are given. Heatmap showing the top enriched Molecular Function GO terms associated to the lists of genes targeted by the top five ranking clusters obtained with recurrent trans-factors (E) or with sporadic trans-factors (F) are shown. Singletons were excluded from the analyses.