Large PKS-I/NRPS hybrid gene clusters found in N. otitidiscaviarum , N. brasiliensis HUJEG-1 and IFM 10847 (Figure 2#20). A; The hybrid gene cluster found in N. otitidiscaviarum. B and C; N. brasiliensis HUJEG-1 and IFM 10847 have only the left half of the hybrid cluster shown in A. A similar cluster in N. brasiliensis NBRC 14402T is truncated at an edge of a contig, and not shown here. D and E; Clusters similar to the one in A are found in Rhodococcus opacus B4 (D) , and Rhodococcus jostii RHA1 (E) . Loci of the left clusters and the right two NRPS clusters are separated in Rhodococcus genomes.