Figure 3
From: Inference of high resolution HLA types using genome-wide RNA or DNA sequencing reads
Impact of read length, coverage and sequencing protocols on HLA typing accuracy. The plot summarizes the HLA typing accuracy of PHLAT using samples from the HapMap RNAseq (top panel), the 1000 Genome WXS (middle panel) and the HapMap WXS (bottom panel) datasets. Prediction accuracies are calculated by considering the sequencing data as either paired-end (close symbols and solid lines) or single-end (open symbols and dashed lines). The symbols represent the mean accuracy at four-digit resolution of the samples that are binned by their fold coverage at the HLA loci, with the error bars indicating the variance. The post-mapping fold coverage is calculated regarding to the CDS regions of the major class I and II HLA loci, excluding the reads suboptimal or not aligned to the candidate alleles. The smooth lines by spline interpolation illustrate the trend of the symbols.