Skip to main content

Table 6 Empirical type I error rates and powers for each method from 1000 replicates at significance level 0.05 when the sample sizes are 1000 for cases and controls and the genotype frequencies for controls are (0.1,0.36,0.54) with major allele is the disease allele

From: A new association test based on disease allele selection for case–control genome-wide association studies

Λ 1 Λ 2

(1,1)

(1, 1.4) RM*

(1.1, 1.4)

(1.2, 1.4) AM*

(1.3, 1.4)

(1.4, 1.4) DM*

(1.5,1.4) ODM*

(0.9, 1.4) UDM*

ChiSQ

0.042

0.55

0.553

0.673

0.812

0.927

0.981

0.749

MAX3

0.044

0.568

0.6

0.718

0.843

0.939

0.987

0.712

GMS

0.041

0.585

0.61

0.718

0.82

0.922

0.98

0.727

CATT

0.041

0.431

0.607

0.765

0.854

0.918

0.962

0.248

MERT

0.042

0.512

0.635

0.755

0.808

0.866

0.896

0.385

GGM

0.036

0.55

0.611

0.743

0.848

0.942

0.986

0.66

New

0.043

0.552

0.597

0.734

0.849

0.941

0.981

0.654

  1. *RM: Recessive Model; AM: Additive Model; DM: Dominant Model; ODM: Over-dominant Model; UDM: Under-dominant Model.