Figure 1

Morphological differentiation of mycelia in Amycolatopsis orientalis HCCB10007 and chemical structures of vancomycin variants. Scanning electron micrograph of A. orientalis HCCB10007 cultured for one or three incubation days (upper left of the panel). The red arrow indicates the sporulation of A. orientalis cultured for three days. The core structural formula proposed for vancomycin and its variants (upper right of the panel) shows minor modifications of the heptapeptide core of vancomycin. Table below shows the specific formulae and radical compositions of each vancomycin variant compounds. Alphabetic numbering in the table are corresponding to the legend of Figure 6.