Figure 4

Analysis of the distances between multiple splicing decision sites. A) Definition of the inter-site distance: Δ. B) The observed distribution of inter-site distances within MASS genes was compared to a simulated distribution based on a model picking random inter-site distances in a simulated pool of 6510 transcripts. The total gene length and intron length distributions in the simulated pool were the same as the ones in the MASS genes (*p < .001 by Mann Whitney U tests). C) Inter-site distance distributions for subsets of MASS genes harboring specific IMMADs were compared to the random model and to the full MASS gene interval distributions. A Kruskal-Wallis test indicated a significant gene group effect (p < .001). Mann-Whitney U tests were performed to compare each IMMAD-specific group to the random model and to the MASS gene group, respectively. **p < .01; *p < .05 versus random model; ##, p < .01; #, p < .05 versus the MASS genes. IMMAD groups depicted in grey displayed no significant differences with either control groups.