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Table 2 Comparison of the association of GRSSs with BMI constructed by count and weighted methods

From: On the association of common and rare genetic variation influencing body mass index: a combined SNP and CNV analysis

GRSS Method

Mean (SD)

ES (SE)

T

p-value

R 2

1. Proxy count

0.450 (0.06)

0.927 (0.129)

7.18

9.07×10−13

0.022

2. Proxy weighted

0.063 (0.01)

1.104 (0.129)

8.56

2.05×10−17

0.027

3. Imputed count

0.447 (0.05)

0.865 (0.121)

7.16

1.11×10−12

0.022

4. Imputed weighted

0.062 (0.01)

1.035 (0.122)

8.51

2.94×10−17

0.030

5. Imputed probability count

0.894 (0.11)

0.872 (0.121)

7.21

7.33×10−13

0.022

6. Imputed probability weighted

0.124 (0.02)

1.037 (0.122)

8.54

2.43×10−17

0.031

  1. Note: BMI = body mass index kg/m2, GRSS = genetic risk sum score, Mean = mean GRSS, ES = effect size for GRSS, Count = GRSS constructed from the summation of the number of risk alleles, Weighted = GRSS constructed from the number of risk alleles weighted by effect-sizes reported in Speliotes et al. 2010, SNP = single nucleotide polymorphism, Proxy = highly correlated substitute SNPs were used for variants not directly genotyped, Imputed = genotypes inferred from 1000 Genomes reference panel, Imputed probability = probability of genotypes inferred from 1000 Genomes reference panel.