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Figure 1 | BMC Genomics

Figure 1

From: Nucleotide excision repair/transcription gene defects in the fetus and impaired TFIIH-mediated function in transcription in placenta leading to preeclampsia

Figure 1

Placental gene expression profiles in a preeclampsia case-control study (GSE10588) [23]. Panel a. Network of significant connections (edges) between the genes (nodes). Size of each node (representing an expressed gene) is proportional to the number of interactions with other genes and is, therefore, directly proportional to the number of significant associations found. Panel b. Bar graph of the number of connections for the most interconnected genes in the network predicted by ARACNE. GTF2E1 was identified as the gene with the largest number of interactions/connections in the network. Panel c. Subnetwork of GFT2E1-regulated genes. Panel d. Canonical pathway analysis of GTF2E1-regulated genes. Panel e: Cytoscape visualization of dysregulated protein-protein interaction networks. Green nodes signify downregulation and red nodes upregulation of each gene product.

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BMC Genomics

ISSN: 1471-2164

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