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Figure 2 | BMC Genomics

Figure 2

From: Nucleotide excision repair/transcription gene defects in the fetus and impaired TFIIH-mediated function in transcription in placenta leading to preeclampsia

Figure 2

Analysis of a human umbilical vein endothelial cells dataset (GSE 27871) [27] created using siRNA-mediated knockdown of 400 specific signaling molecules and transcription factors. Panel a. Pearson correlation analysis of FLT1 siRNA-mediated knockdown with other datasets revealing a common gene regulatory network of GTF2E1 and FLT1. Panel b. Pearson correlation analysis of GTF2E1 siRNA-mediated knockdown with other datasets revealing a common gene regulatory network of GTF2E1 and FLT1. Panel c. Correlation matrix of all siRNA-mediated knockdowns revealing significant (r > 0.95) gene clusters. The gene cluster connecting GTF2E1 and FLT1 (i.e., GTF-FLT-HDA-HSF gene cluster) is shown in green.

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BMC Genomics

ISSN: 1471-2164

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