Figure 5

Graphical depiction of our proposed mechanism of impairment of TFIIH-mediated function in transcription in placenta leading to preeclampsia. We propose that impairment of TFIIH-mediated function in transcription, which may occur via several mechanisms such as mutations in the genes coding for subunits of its core domain (such as TTD-associated mutations in XPD, XPB and TTD-A), downregulation of the subunits of its CAK domain, and/or dysregulation of subunits of other transcription factors with which it interacts such as GTF2E1 of TFIIE, is one mechanism leading to preeclampsia. Red arrows depict downregulation. Yellow symbols depict mutations.