Figure 4

Direct connection sub-networks for most highly top 10% connected genes from each module of separate network for male (a) or female (b). Only directly connected genes are shown according to their location in the cell (on membrane, in Golgi apparatus, nucleus, cytoplasm or outside the cell). Node shapes and color code: oval and circle – protein; diamond – ligand; circle/oval on tripod platform – transcription factor; ice cream cone – receptor; crescent – kinase or protein kinase; irregular polygon – phosphatase; red color indicates up-regulated genes, blue – down-regulated. Arrows with plus sign show positive regulation/activation, arrows with minus sign – negative regulation/inhibition; grey arrows represent regulation, lilac - expression, purple – binding, green – promoter binding, and yellow – protein modification.