Table 4 Genes of reference H. influenzae strains that are absent in the Hif KR494 genome

  Histidine biosynthesis pathway

  HI0468-HI0474*

his ABCDEFGH operon

  HI0475

his IE

  Other amino acid biosynthesis pathway

  HI0607

Shikimate 5-dehydrogenase, aroE (phenylalanine, tyrosine and tryptophan)

  HI0737

Acetohydroxy acid synthase II (valine, leucine and isoleucine)

  Anaerobic fermentation of L-ascorbate

  HI1024-HI1026*

ula DEF operon

   HI1027

Lyx

  HI1031

2,3-diketo-L-gulonate reductase

  Folate biosynthesis

  HI1190*

6-pyruvoyl tetrahydrobiopterin synthase

  HI1464

Dihydropteroate synthase

  Secondary molybdenum transporter

  HI1469

mod A

  HI1470-HI1472*

mol ABC

  HI1473-HI1475

mod D-sal X-cys U

  HI1525

mod A

  LOS biosynthesis

  HI0867-HI0874*

hmg locus (sia A, wba P, rff G)

  HI1578

Glycosyl transferase WcaA

  HIB_08850^c

UDP-glucose--lipooligosaccharide glucosyltransferase

  Iron and zinc transporter

  HIB_07090^c, *

Zinc transporter ZitB

  HI0291

Periplasmic mercury transport-like protein

  HI0661

Hemoglobin-binding protein OapA

  HI0712

Hemoglobin-binding protein

  Other metabolism

  HI0053

Zinc-type alcohol dehydrogenase (fructose and mannose metabolism)

  HI0692

Xanthine-guanine phosphoribosyltransferase (purine metabolism)

  HI1649

D-lactate dehydrogenase (pyruvate metabolism)

  Others

  HI0584

Peptidase, aminobenzoyl-glutamate utilization protein

  HI0947

Virulence-associated protein C

  HI1251

Virulence-associated protein A

  HI1465

Cell division FtsH-like protein