Figure 1

The chemical space of plants associated with colon cancer. (A) A sub list containing 39 plants that are considered typical for western diet; the embedded figure shows the compound distribution as found in the 159 edible and non-edible plants. Green indicates total number of compounds, while orange indicates compounds that were found as exact match in CHEMBL; (B) Clustering of the plant compounds (green), human colon metabolites (yellow), FDA approved drugs (purple) and anticancer FDA approved drugs (black cross) based on 1027 chemical descriptors. Selected compounds ((i)-(viii)) from the plant chemical space that show either no chemical similarity with the other groups of compounds are shown on the left or low chemical similarity only with drugs are shown on the right.