Figure 2

The interactome space of the edible plants associated to colon cancer. (A) (i) The pie chart offers information for the compounds present in these edible plants; phytochemicals found as exact match in ChEMBL (orange), phytochemicals having at least one similar small molecule present in ChEMBL (blue) phytochemicals that do not fulfill any of the above criteria (green); (ii) A graphical representation of how the interactome map between edible plants and candidate colon cancer protein targets was generated: (a) an edible plant (orange circle; Px) contains a phytochemical (box; Cx) which interacts directly with a target protein (green diamond; TPx) or through a first-degree neighbor (yellow diamond; Py) of TPx, (b) the phytochemical Cx is structurally similar with a compound (Cy) that interacts with the target protein (TPx). Straight lines represent verified interactions while dashed lines represent predictions; (iii) The Venn diagram shows the overlap between the proteins in the three candidate colon cancer target sets; (B) A plant-protein interaction network based on the interactions between phytochemicals, FDA approved colon cancer drug targets and their first-degree neighbors. The size of the plant node is proportional to the number of proteins that its molecular components target. The width of the edge connecting two plants reflects how many protein targets the plants share. (C) A plant-protein interaction network using as a candidate target space the KEGG colon cancer pathway. (D) A plant-protein interaction network using as a candidate target space the colon cancer prognostic gene signatures (Oh et al., 2012) [13]. The color of the nodes in (B)-(D) is according to (Aii).