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Figure 4 | BMC Genomics

Figure 4

From: Exploring mechanisms of diet-colon cancer associations through candidate molecular interaction networks

Figure 4

The highly active edible plant space and the highly correlated colon cancer target space. (A)-(B): The two tables show the efficacy of each plant (for details see Methods) calculated using either (A): a binary index; 0 = no phytochemicals in the plant interact with the protein (proteins in the tables are indicated as X1-Xn), 1 = at least one phytochemical in the plant interacts with the protein, or (B): the number of unique phytochemicals present in the plant that interact with the protein. (C): A network of candidate colon cancer proteins connected by the phi correlation coefficient. Labels on the edges are the phi correlation coefficients. The network shows only significant correlations (p < 0.05, Bonferonni corrected). Correlation coefficients are calculated using the knowledge of plant-protein interactions, and thus a large correlation coefficient indicates that these two proteins are targeted by a common set of plants. The node size is proportional to the actual number of plants targeting a protein. The equations used to calculate the correlation coefficients are shown on the right, in which the squared phi coefficient is related to the Chi-squared test statistic by the number of samples.

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