Figure 2

GO term visualization (BP) for gene groups of interest. The scatterplot shows the terms after redundancy reduction via REViGO, representing functional clusters. The bubble color indicates the p-values of the topGO analysis, and the bubble size indicates the frequency of the GO term in the underlying GOA database, i.e. the more general the term, the larger the bubbles. The GO terms cluster together in the semantic space according to functional similarity, without intrinsic meaning of semantic space units. A: TC:up/TL:up (“translation group”), B: TC:up/TL:down (“thrombospondin group”), C: TC:unchanged/TL:down (“methylation and repair group”), D: TC:down/TL:unchanged (“regulation group”).