Figure 5

Top canonical pathways mapped in Ingenuity Pathway Analysis (A) and GO terms classified under biological process (B) for a selected set of genes differentially regulated between healthy and atretic follicles. In A the bar chart on the left represents the percentage of genes that map to each canonical pathway, showing those which are up regulated (in red) and down regulated (in blue) in atretic with respect to healthy follicles. The line chart on the right ranks these pathways derived for the same dataset, from the highest to lowest degree of association based on the value of a right-tailed Fishers exact t test (black), and the Benjamini-Hochberg False Discovery rate test for multiple comparisons (red) (top to bottom in graph on right). In B the significance of association was determined by the Benjamini-Yuketeli test for multiple comparisons. The bar chart indicates the percentage of genes that map to a GO term which are differentially regulated (in blue). Only those significantly enriched GO terms associated with a subset of genes of the most specific function were presented, to avoid terms which were too general and of limited value.