Figure 7

Two statistically significant networks (A and B) produced by mapping differentially expressed genes between healthy and atretic follicles to molecules in the IPA database. The networks are generated in IPA using triangle connectivity based on focus genes (those present in our dataset) and built according to the number of interactions between a single prospective gene and others in the existing network, and the number of interactions the prospective gene has outside this network with other genes as determined by IPA [20]. Interactions between molecules, and the degree and direction of regulation are indicated similarly as in Figure 6 with up (red) or down regulation (green) and increasing colour intensity with degree of fold change.