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Table 3 Genes which were up regulated in small atretic follicles with respect to healthy follicles

From: Transcriptome profiling of granulosa cells from bovine ovarian follicles during atresia

Gene symbol Fold change Gene symbol Fold change Gene symbol Fold change
Cell Cycle and DNA replication
CDKN1C 40.2 RGCC 5.1 IFITM3 3.3
MICAL1 8.9 TOP1 5.1 DYNLT3 3.1
CDC37L1 5.9 RAD52 3.5 BAZ1A 3.0
TOPORS 5.7 KLC1 3.4   
Cell Death
TNFRSF12A 10.4 *PHLDA1 4.7 TNFRSF25 3.4
CFLAR 6.0 PDCD4 3.9 TNFRSF1A 3.2
TNFRSF6B 5.9 FAIM 3.8 PDCD10 3.1
Cell Morphology
MAP1LC3C 16.7 APBB1IP 4.6 SNTB2 4.0
CAPG 11.1 MAP2 4.5 MTMR3 3.8
TAGLN 10.8 CNN1 4.4 LMNA 3.5
DBNDD2 9.2 AIF1L 4.4 ABLIM1 3.5
NDRG1 9.0 VCL 4.3 FHOD3 3.4
SYNE1 7.6 WASL 4.3 MARCKSL1 3.2
CLDN5 6.3 CDH1 4.3 MAP9 3.2
SVIL 6.1 ACTA2 4.3 MICAL2 3.1
MICALL2 6.1 TAGLN2 4.3 ELMO1 3.1
FILIP1L 5.6 FSCN1 4.2 ELMO2 3.1
ARPC1B 5.5 FNBP1L 4.1 *ARF5 3.1
FERMT2 5.4 TLN1 4.1 TPGS1 3.0
GSN 5.3 ACTN1 4.1 B9D2 3.0
TUBB6 5.1 DSTN 4.0 FBLIM1 3.0
CAV1 4.6 RILPL2 4.0   
Cytokines, Hormones and Receptors
PDGFRA 26.5 IGF2R 6.2 CD302 3.7
SCG2 24.4 ELTD1 6.1 JAG1 3.6
CTGF 23.4 TSPO 5.7 IL10RA 3.6
DKK3 17.4 IGFBP6 5.1 PTPRK 3.6
XCL1 16.7 IGF2 5.0 PLXND1 3.6
SPP1 14.1 TGFBR2 5.0 CMTM3 3.5
OLR1 11.7 MIA3 4.6 IL17RA 3.5
MDK 9.9 IFI30 4.5 NR4A2 3.5
IL18 8.9 IGFBP5 4.3 ANGPTL4 3.4
PRICKLE1 8.2 EFNA4 4.2 EFNA5 3.3
BAMBI 7.6 NR2F1 4.1 GPRC5B 3.3
NDP 7.6 ADM 3.9 GPR155 3.3
GNG2 7.3 PLXNB2 3.8 ACVR1 3.1
PLAUR 6.7 *PVRL2 3.8 SCG5 3.1
BMP2 6.6     
Directional Cell Growth
SLITRK2 4.3 ROCK2 3.8 ROCK1 3.3
Extracellular Matrix and Synthesis
*SPOCK2 23.8 TNFAIP6 7.1 COL18A1 4.0
*NID2 18.5 LOXL4 6.5 *FN1 3.9
*LEPREL1 12.8 LUM 6.1 FBN1 3.8
LAMB1 12.0 COL3A1 5.5 COL4A5 3.5
DCN 11.1 COL1A2 5.3 SPON2 3.5
MGP 9.5 PCOLCE2 4.6 SDC4 3.4
SDC2 9.0 COL4A1 4.5 COL12A1 3.4
FBLN2 8.7 AGRN 4.1 COL6A1 3.2
COL5A2 8.3     
Intercellular and Cell to Matrix Adhesion
KRT18 62.4 CLDN1 10.2 MAGI3 4.6
KRT8 53.2 CD9 7.1 AMIGO2 4.5
PTX3 24.1 PCDH7 7.0 ANTXR2 3.7
THBS2 23.9 FLNB 6.6 SPARC 3.6
LGALS3 22.9 MAGI1 6.0 CADM1 3.3
*CD24 17.1 VMP1 5.3 JAM3 3.2
CYR61 14.1 CLDN11 4.9 CCDC80 3.0
CALD1 11.6     
Ion Transport
KCNMB4 5.7 CACNB3 4.0 KCTD10 3.8
GPM6A 4.8 CLCA4 3.9 SEPP1 3.7
CLIC4 4.5 SCN5A 3.9 KCNJ2 3.7
Protein Trafficking
ANXA1 10.9 SCG3 4.0 PLEKHB2 3.6
GABARAPL1 6.2 CHMP5 3.7 SCAP 3.4
GIT2 4.4 MVP 3.7 PLEKHG2 3.3
SH3RF1 4.0     
Proteolysis or Inhibition
TIMP1 68.9 CAST 6.7 CTSZ 3.5
PLAT 26.5 ADAMTS1 6.1 FBXO32 3.3
SERPINE1 19.3 C1S 5.9 TIMP2 3.3
PRSS23 10.9 CTSH 4.7 CTSK 3.2
CSTB 9.3 MMP11 4.4 CTSB 3.2
RELN 7.7 CTSS 4.4 KLHL36 3.2
MMP23B 7.7 CFD 3.8 SERPINB2 3.1
SERPINB8 7.4 PSMB1 3.5 LYZ 3.0
RNA Processing
PRPF38B 7.1 RBM25 3.9 SNRNP200 3.2
RBMS2 6.3 DDX5 3.7 HNRNPH3 3.2
RBM24 4.6 SYNCRIP 3.6 CPEB4 3.2
RBM17 4.5 DDX42 3.6 EBNA1BP2 3.1
TDRD7 4.3 INTS7 3.3 GEMIN8 3.1
REXO2 4.0 CWC22 3.2   
Transcription Regulation
ANKRD1 48.9 TAX1BP3 4.8 LEF1 3.4
FOSL2 11.7 *MLL3 4.7 TGIF1 3.4
EGR1 11.3 MTPN 4.6 MPHOSPH8 3.4
ATF3 9.7 EPAS1 4.6 MORF4L2 3.3
BCL6 8.6 FOXP1 4.5 MAFK 3.3
ATRX 8.4 ING4 4.4 CSRNP1 3.3
ID1 7.4 GTF2F2 4.4 LARP7 3.3
USF1 6.8 SMAD3 4.3 GTF2E2 3.3
KLF6 6.5 STAT3 4.3 GTF2H4 3.3
RBFOX2 6.5 SERTAD1 4.3 BASP1 3.3
JUN 6.4 HHEX 4.2 LEO1 3.3
CEBPD 6.0 ZNF398 4.2 TCF3 3.3
ID3 5.8 HMBOX1 4.0 ZMIZ2 3.2
*TCF7L2 5.8 PDLIM1 3.9 NFKBIA 3.2
HDAC7 5.8 ZFP36L1 3.9 ZC3H8 3.2
NMI 5.7 JUNB 3.9 OSTF1 3.2
SNAI2 5.7 E4F1 3.9 CIR1 3.2
ZNF292 5.7 ZNF281 3.8 ZNHIT3 3.1
LITAF 5.6 FOS 3.7 GPS2 3.1
CITED2 5.6 FHL2 3.7 CSDC2 3.1
CTR9 5.5 CYLD 3.7 KHDRBS1 3.0
*CEBPD 5.4 TRANK1 3.6 ILF3 3.0
KANK2 5.1 FOXO1 3.6 ANKRD10 3.0
NFIL3 5.0 *CPEB2 3.6   
JARID2 4.9 SCAND1 3.5   
MXI1 4.9 HDAC5 3.5   
Translation Regulation
MRPS28 3.6 EIF4G3 3.2 EIF2AK4 3.2
EIF2AK4 3.5     
Transport
APOD 37.5 SLC25A29 4.2 RBP1 3.4
STAR 22.5 STAU1 4.1 TCN2 3.4
SLC17A5 9.0 VPS13B 4.1 SLC25A17 3.4
FABP5 8.9 STEAP1 4.0 CYTH3 3.4
A2M 8.1 RABEP1 3.9 SYT11 3.2
NNAT 7.8 *ABCB1 3.8 FABP4 3.1
SLC40A1 7.2 CRABP2 3.7 AP1S2 3.1
VAT1 6.8 STARD3NL 3.7 NPC2 3.0
SLC39A8 5.2 ANKH 3.6 SNX9 3.0
Other Enzymes
*VNN1 15.1 PNMT 4.1 RAB31 3.2
*PDK4 9.7 HSP90AA1 4.0 PTPRN2 3.2
GFPT2 7.8 RAP2C 4.0 RIOK2 3.2
QSOX1 5.9 SETD7 4.0 RNF20 3.2
DDAH2 5.5 CHST2 4.0 LHFPL2 3.2
GLRX 5.4 SMS 3.8 PTPN21 3.2
PLSCR4 5.4 NT5E 3.8 RAB7A 3.1
ENPP5 4.9 MARCKS 3.7 DDAH1 3.1
PYGL 4.9 GDPD1 3.6 PPIE 3.1
CA2 4.8 DUSP7 3.6 ARF5 3.1
RPIA 4.7 EGLN1 3.5 RBKS 3.1
PELI1 4.7 ZNRF1 3.4 UST 3.1
MYCBP2 4.6 NAGK 3.4 ENO2 3.1
CPT1A 4.5 MGST2 3.4 RNF8 3.1
GEM 4.4 B4GALT5 3.4 PLCL2 3.0
PIGT 4.3 RAB22A 3.3 DPH5 3.0
DUSP1 4.3 ALDH1A1 3.3 IP6K2 3.0
PXDN 4.2     
Other Signalling
*RND3 35.7 EFHD2 5.8 SHISA2 3.9
*DCLK1 19.5 JAK1 5.7 RALA 3.9
GAL 10.6 VAV2 5.6 CSNK2A1 3.7
POSTN 9.9 INSIG2 5.4 BMPER 3.7
ARHGEF11 9.9 WDR44 5.0 ARHGAP32 3.5
TP53INP1 8.9 STK17A 5.0 S100A11 3.3
LMTK2 8.1 PTPN5 4.6 UACA 3.2
SH3BP5 7.5 WHSC1L1 4.5 ERBB2 3.2
GIMAP8 7.5 IRAK1BP1 4.4 FYN 3.2
SH3KBP1 7.4 CFH 4.4 CORO1A 3.2
ARHGEF3 7.1 IFITM1 4.3 BCAR1 3.1
RSPO3 7.1 PIK3CA 4.3 DOCK5 3.1
CD200 7.0 DAB2 4.3 PIK3CD 3.1
PLIN2 6.6 CSNK1G2 4.2 STK38L 3.1
PKIB 6.5 MERTK 4.1 MAP2K3 3.1
FBXO33 6.2 RASA2 4.1 TYRO3 3.1
CD55 6.2 PIM1 4.0 CARD10 3.1
ERRFI1 6.1     
CD99 6.0     
DAPP1 5.8     
Other
C8orf4 37.2 RCN2 4.4 CBLB 3.6
SATL1 15.2 KIAA1598 4.4 ASCC2 3.5
WDFY4 11.1 FAM126B 4.4 FAM32A 3.5
PLXDC2 9.1 ZNF317 4.2 OCIAD2 3.5
LUC7L3 8.9 C1orf35 4.2 SAFB2 3.5
ZNF462 7.5 RASAL2 4.2 ALKBH4 3.4
NTN4 7.3 AKAP8L 4.1 TSC22D3 3.4
KIAA0408 7.2 DENND3 4.1 IRGQ 3.4
RSRC2 7.1 C1QTNF6 4.1 AUTS2 3.4
C10orf10 7.0 CCDC85B 4.1 GATSL2 3.4
PHF3 6.4 ARHGEF2 4.0 COMMD4 3.4
SDE2 6.3 MAP1B 4.0 MLLT11 3.3
BTBD3 6.1 C3orf19 4.0 ZFYVE1 3.3
TMEM14A 5.9 CUL9 4.0 PPFIBP1 3.3
ODF2L 5.8 MAP7D1 3.9 FAM129B 3.3
MXRA8 5.8 MTA3 3.9 FLRT2 3.3
GLIPR2 5.6 LIMCH1 3.9 PRRC2C 3.2
NDRG4 5.6 KLHL24 3.9 GPN3 3.2
TMEM176A 5.4 CXorf26 3.9 MESDC1 3.2
MXRA5 5.3 SHF 3.9 ARMCX3 3.2
CRYAB 5.1 YPEL5 3.9 SNN 3.2
C7orf41 4.9 PQLC3 3.9 KIAA0922 3.2
ZNF608 4.9 TMTC2 3.9 TCP11L2 3.2
KLHL28 4.9 HECA 3.8 ANKRD11 3.2
PLEKHO1 4.8 C9orf3 3.8 C1orf212 3.1
TACC2 4.8 LRCH1 3.8 TMEM176B 3.1
GOLPH3L 4.8 DPH3 3.7 SYAP1 3.1
ERRFI1 4.7 CD83 3.7 METRNL 3.1
SRP14 4.7 CTTNBP2NL 3.7 FAM160A2 3.1
ZDHHC23 4.7 TES 3.7 MEF2BNB 3.1
EML1 4.7 GLTSCR2 3.7 C5orf30 3.1
ANXA2 4.7 CLU 3.6 ATG14 3.1
ZNF521 4.6 LHFP 3.6 BOD1L1 3.1
PDLIM4 4.6 PKIG 3.6 DEFB4A 3.0
KIAA0232 4.4 LSG1 3.6 C17orf101 3.0
C12orf75 4.4     
  1. Differentially regulated genes (> 3 fold, P < 0.05) were annotated based on the Entrez Gene database. Genes are listed in descending order of fold change within each functional category.
  2. † Benjamini-Hochberg post-hoc test for multiple corrections following one way ANOVA.
  3. * Indicates genes determined from the Partek analysis based on the Affymetrix annotations which were not assigned identities by IPA.