Table 8 Upstream regulators predicted by target gene expression in the atretic versus healthy dataset
From: Transcriptome profiling of granulosa cells from bovine ovarian follicles during atresia
Upstream regulator | Predicted activation state | Bias-corrected z-Score | P value of overlap | Target molecules in dataset |
|---|---|---|---|---|
TP53 | activated | 4.272 | 5.78E-11 | ALB, ANXA1, ANXA2, ARHGEF2, ARPC1B, ATF3, CALD1, CAV1, CFLAR, CLIC4, CNN1, COL18A1, COL1A2, COL3A1, COL4A1, CTGF, CTSH, CYR61, DKK3, DUSP1, EGR1, FBLN2, FERMT2, GADD45A, GLRX, GPX3, GSN, HMGCS1, ID1, ID3, IER3, IFI30, IGF2, IGFBP5, JUN, KRT8, LGALS3, MAP4K1, MMP23B, MPDZ, NDRG1, NOS2, NR2F1, PCDH7, PDE6A, PGFRA, PHLDA1, PIM1, PLAUR, POSTN, RAD51AP1, SAT1, SERPINE1, SGK1, SNAI2, SPP1, STAU1, STK17A, TAGLN2, TGFBR2, THBS2, TOP2A, TP53INP1, VCL, VEGFA |
FOXO4 | activated | 2.203 | 5.41E-05 | BCL6, CTGF, GADD45A, HMGCS1, IER3, SERPINE1, SGK1, VEGFA |
CEBPB | activated | 2.142 | 1.59E-07 | ALB, CEBPD, COL1A2, CPT1A, CSN2, CYP19A1, DAB2, DCN, GADD45A, GLIPR2, ID1, IFIT, M3, MGP, MMP11, NDRG4, NOS2, PDGFRA, PDK4, PLAUR, SAT1, SERPINE1, SGK1, SPP1, STAR, TMEM176A, TNFAIP6, TOP1 |
RXRA | inhibited | -2.100 | 3.52E-04 | CEBPD, CPT1A, CYP2C9, FABP5, GCLC, GPT, IER3, LPL, MGP, MMP11, OLR1, PNMT, SAT1, SLC10A2, SPP1, STAR, VEGFA |
HNF1A | inhibited | -2.168 | 4.07E-01 | ALB, BCL6, C1S, CD55, COL3A1, IHH, SERPINE1, SLC10A2, SLC40A1, SLC4A2, UGT2B4 |
MYC | inhibited | -3.197 | 7.80E-07 | ACTN1, ALB, AQP1, BCL6, CALD1, CAST, CAV1, CD9, CEBPD, CFLAR, CLIC4, COL1A2, COL3A1, COL4A1, CPT1A, CSTB, DSTN, DUSP1, FABP5, FBLN2, GADD45A, GCLC, GTF2F2, HLA-A, ID1, ID3, IER3, KLF6, LUM, NDRG1, PLAUR, PLP1, POLR3D, SGK1, SPP1, TAGLN2, TGFBR2, THBS2, TIMP1, TLN1, TSPO, VEGFA |
MYCN | inhibited | -3.202 | 8.50E-03 | ARPC1B, CAV1, CCNT1, CITED2, COL18A1, COL4A1, CTGF, DKK3, FGFR2, HLA-A, SDC2, SERPINE1, TAGLN |