Relevant genes in loci from the WTCCC GWAS depending on gene definitions. Image modified form Figure five of the WTCCC 2007 GWAS paper with permision . Horizontal lines corresponding to the genes overlaping with the region of association have been added in the middle panel of A) B) and C), in red for the ± 50 Kb rule and in green for the SRR ≥ 2 definition. No lines were added for panel D). Association region in each locus is limited by vertical dotted lines. The upper panel represents the SNPs (black dots, genotyped; grey dots, imputed) in function of position (X axis) and association (Y axis = -log10(P)). Middle panel, centimorgans per Mb estimated from Phase II HapMap. The purple line shows the cumulative genetic distance (in cM) from the hit SNP. Lower panel, known genes in orange, top track shows plus-strand genes and the middle track shows minus-strand genes in condensed format. Below these tracks, sequence conservation in 17 vertebrates. Information in middle and lower panels is from the UCSC Genome Browser. Positions are in NCBI build-35 coordinates. Known genes in the hit region according the WTCCC paper are listed in the upper right part.