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Table 1 Number of genes in association regions of the WTCCC GWAS top hits[19]

From: Genetic distance as an alternative to physical distance for definition of gene units in association studies

Chromosome Diseaseb WTCCC SRR ≥ 2c ± 50 Kbc
5p13 CD 0 - -
10q24 CD 1 - -
10q25 T2D 1 - -
9p21 CAD 2 - -
10q21 CD 3 - -
16q12 CD 4 - -
16q12 T2D 1 - + 1
5q33 CD 2 - + 1
1p13 a RA 7 - + 1
1p13 a T1D 7 - + 1
16p13 T1D 8 - + 1
16p12 BD 9 - + 1
1p31 CD 1 - + 2
2q37 CD 1 - + 2
18p11 CD 1 - + 2
12q24 T1D 15 - + 2
12q13 T1D 26 - + 3
3p21 CD 18 + 7 + 9
  Total 107 + 7 + 26
  1. aThese two loci overlap.
  2. bCD = Crohn’s disease, T2D = Type 2 diabetes, CAD = Coronary artery disease, RA = Rheumatoid arthrtitis, T1D = Type 1 diabetes, BD = Bipolar disorder.
  3. cSRR ≥ 2 for the gene definition extended to reach a cumulative SRR ≥ 2 in each direction; and ± 50 Kb for gene definition extended to this length in each direction. Only changes in the number of genes, not in their identity, were observed between the three lists:- no differences with the genes highlighted by the WTCCC authors; + number of additional genes beyond the highlighted by the WTCCC authors. A full list of genes in each loci is available as Additional file 1: Table S1.