Table 3 Probes both differentially methylated and expressed in association with prednisolone response
| Â | Â | Â | Expression | Methylation | Â | Â |
|---|---|---|---|---|---|---|
Threshold | Gene_symbol.x | Gene_description.x | adj.P.Val | adj.P.Val | methDiff | expDiff |
Upregulated and less methylated in PPR | H2AFY2 | H2A histone family, member Y2 | 0.1173 | 0.1782 | -0.2204 | 4.0116 |
(>2-fold expression, <-0.2 methylation) | H2AFY2 | H2A histone family, member Y2 | 0.1173 | 0.3973 | -0.3007 | 4.0116 |
| Â | MTX2 | Metaxin 2 | 0.0190 | 0.3673 | -0.4061 | 3.9695 |
| Â | PAWR | PRKC, apoptosis, WT1, regulator | 0.0000 | 0.3154 | -0.4185 | 3.6350 |
| Â | PAWR | PRKC, apoptosis, WT1, regulator | 0.0000 | 0.3973 | -0.3026 | 3.6350 |
| Â | MYO3A | Myosin IIIA | 0.0305 | 0.2944 | -0.4156 | 3.4893 |
| Â | MYO3A | Myosin IIIA | 0.0305 | 0.3154 | -0.4006 | 3.4893 |
| Â | MTX2 | Metaxin 2 | 0.0119 | 0.3673 | -0.4061 | 3.1908 |
| Â | BX537570 | Â | 0.2492 | 0.0333 | -0.3571 | 3.1574 |
| Â | BX537570 | Â | 0.2492 | 0.1707 | -0.4761 | 3.1574 |
| Â | CTSC | Cathepsin C | 0.0624 | 0.1782 | -0.4239 | 2.6472 |
| Â | CTSC | Cathepsin C | 0.0624 | 0.2267 | -0.2834 | 2.6472 |
| Â | CTSC | Cathepsin C | 0.0766 | 0.1782 | -0.2834 | 2.5574 |
| Â | CTSC | Cathepsin C | 0.0766 | 0.2267 | -0.4239 | 2.5574 |
| Â | MOSC1 | MOCO sulphurase C-terminal domain containing 1 | 0.0578 | 0.5189 | -0.2051 | 2.5035 |
| Â | NGFRAP1 | Nerve growth factor receptor (TNFRSF16) associated protein 1 | 0.4360 | 0.4775 | -0.2504 | 2.4066 |
| Â | MARCKS | Myristoylated alanine-rich protein kinase C substrate | 0.5467 | 0.4154 | -0.2603 | 2.3418 |
| Â | MPO | Myeloperoxidase | 0.5920 | 0.4097 | -0.2226 | 2.3130 |
| Â | CTSC | Cathepsin C | 0.0578 | 0.1782 | -0.2834 | 2.1699 |
| Â | CTSC | Cathepsin C | 0.0578 | 0.2267 | -0.4239 | 2.1699 |
| Â | CCR7 | Chemokine (C-C motif) receptor 7 | 0.2918 | 0.4434 | -0.2264 | 2.0570 |
| Â | PLS3 | Plastin 3 (T isoform) | 0.6662 | 0.3610 | -0.2919 | 2.0256 |
Downregulated and more methylated in PPR | POU4F1 | POU class 4 homeobox 1 | 0.1004 | 0.4404 | 0.3017 | -5.3928 |
(<-2-fold expression, >0.2 methylation) | CYB5R2 | Cytochrome b5 reductase 2 | 0.1734 | 0.5066 | 0.2699 | -4.3486 |
| Â | TMED6 | Transmembrane emp24 protein transport domain containing 6 | 0.0504 | 0.5271 | 0.2317 | -4.1584 |
| Â | CRMP1 | Collapsin response mediator protein 1 | 0.3007 | 0.4431 | 0.3668 | -3.8640 |
| Â | CRMP1 | Collapsin response mediator protein 1 | 0.3007 | 0.3996 | 0.2607 | -3.8640 |
| Â | IRX3 | Iroquois homeobox 3 | 0.5401 | 0.4957 | 0.2710 | -2.9003 |
| Â | LDOC1 | Leucine zipper, down-regulated in cancer 1 | 0.2608 | 0.6055 | 0.2578 | -2.4859 |
| Â | DSC3 | Desmocollin 3 | 0.5401 | 0.4585 | 0.3377 | -2.2248 |
| Â | DSC3 | Desmocollin 3 | 0.5401 | 0.4402 | 0.3561 | -2.2248 |
| Â | ANXA5 | Annexin A5 | 0.5923 | 0.3699 | 0.2228 | -2.0708 |
| Â | ANXA5 | Annexin A5 | 0.5923 | 0.3727 | 0.2386 | -2.0708 |