Figure 6

Recombination rates in common population-specific (CPS) SNP-enriched regions. A. The expected and observed number of hotspots (HS), defined on the basis of top 1% and 5% recombination rates) and coldspots (CS) (defined on the basis of lowest 1% and 5% recombination rates) in CPS SNP-enriched regions. (A) Recombination rates for the YRI was estimated on the basis of the HapMap24 YRI specific map downloaded using the UCSC table browser. The distribution of hotspots in regions detected by length based (5-kb) and window based (50-SNP) approaches using the top 1% (indicated with _1) and 5% (shown by _5) recombination rate is shown (B) The combined recombination map was used to identify whether the observed pattern of distribution of hotspots and cold spots in YRI also hold for JPT, LWK and CHINESE population specific windows (based on top 5% recombination rates). In addition to individual populations, the CPS SNP-enriched windows for all four populations taken together (ALL_HS and ALL_CS) are also shown.