Table 4 List of significant gene ontology (GO) terms from GO analysis of genes that exist in the identified across-breed and breed-specific pleiotropic QTL
From: Large-effect pleiotropic or closely linked QTL segregate within and across ten US cattle breeds
GO1 | Term ID | p-value | Term name | Gene list | BTA_Mb2 |
|---|---|---|---|---|---|
BP | GO:0009888 | 5.00E-02 | Tissue development | SLC40A1, HMGA2, LEMD3, FGF6, FGF23, PKD2, SPP1, MEPE, IBSP, ARRDC3, IMPAD1, INSC, SH3PXD2B, NKX2-5 | 2_6, 5_48, 5_106, 6_38, 7_93, 14_25, 15_38, 20_4 |
BP | GO:0001503 | 3.33E-02 | Ossification | FGF23, SPP1, MEPE, IBSP, IMPAD1, CT, CALC3 | 5_106, 6_38, 14_25, 15_38 |
BP | GO:0030279 | 3.25E-03 | Negative regulation of ossification | FGF23, MEPE, CT, CALC3 | 5_106, 6_38, 15_38 |
BP | GO:0060612 | 2.50E-02 | Adipose tissue development | HMGA2, ARRDC3, SH3PXD2B | 5_48, 7_93, 20_4 |
BP | GO:0070887 | 2.54E-02 | Cellular response to chemical stimulus | MSTN, HMGA2, LEMD3, FGF6, FGF23, PKD2, SPP1, IBSP, LYN, CT, CALC3, C5ORF41, STC2 | 2_6, 5_48, 5_106, 6_38, 15_38, 20_4, 29_30 |
BP | GO:2001259 | 2.50E-02 | Positive regulation of cation channel activity | EFCAB4B, PKD2, NKX2-5 | 5_106, 6_38, 20_4 |
BP | GO:1901021 | 1.52E-02 | Positive regulation of calcium ion transmembrane transporter activity | EFCAB4B, PKD2, NKX2-5 | 5_106, 6_38, 20_4 |
ke | KEGG:04010 | 5.00E-02 | MAPK signaling pathway | FGF6, FGF23, C-MOS, RRAS2, DUSP1 | 5_106, 14_24, 15_38, 20_4 |