Tools (Training set) | AUC | Accuracy | Precision | Sensitivity | Specificity |
---|---|---|---|---|---|
Testing set: Swiss-Prot dataset with HumDiv mutations excluded (36998 neutral variants, 17643 damaging variants)* | |||||
EFIN (HumDiv) | 86.96% | 80.71% | 85.96% | 84.96% | 72.16% |
polyphen2 (HumDiv) | 85.26% | 78.35% | 63.27% | 78.59% | 78.24% |
Testing set: Swiss-Prot dataset with HumVar mutations excluded (15819 neutral variants, 2284 damaging variants)* | |||||
EFIN (Swiss-Prot ∩ HumVar)** | 84.91% | 71.37% | 96.72% | 69.60% | 83.64% |
polyphen2 (HumVar) | 80.60% | 78.09% | 32.28% | 67.12% | 79.67% |