Annotated and novel portions of the human PFC transcriptome. (a), (b), (c) The proportion of four transcript types – annotated transcripts (orange), novel elements of annotated transcripts (blue), antisense transcripts (green), and novel intergenic transcripts (purple) – with respect to the total transcriptome length, transcript count and expression level, respectively. (d) Categories of novel elements of annotated transcripts detected in the human PFC transcriptome. Black and grey boxes indicate annotated exons and UTRs, white boxes represent novel transcript elements. The “Support” column shows the percentage of novel transcript isoforms confirmed by Oases and Cufflinks transcriptome assembly algorithms, and additionally supported by H3K4me3 modification peaks and transcript polyA tails (see Methods).