Table 2 SNPs and Indels identified in antibiotic resistance-associated regions in M. tuberculosis isolates
From: Comparative genomic analysis of Mycobacterium tuberculosis clinical isolates
Mutations in target gene or intergenic regions (corresponding drugs)a | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Isolates | Rv1483( mabA)b(INH) | Rv1484 ( inhA) (INH) | Rv1592c (INH) | Rv1908c ( katG) (INH) | Rv2247 ( accD6) (INH) | Rv2428 ( ahpC) (INH) | Rv2846c ( efpA) (INH) | Rv0667 ( rpoB)c(RMP) | Rv0682 ( rpsL) (STR) |
Mtb562 | None | None | T70(del),E321e,f,I322Vf,g | None | None | None | None | A1075e,f | None |
Mtb526 | None | None | T70(del),E321e,f,I322Vf,g | S315Td,g,R463Lg | D200e,f,D229Gg | S40Nf,g | None | L511Pd,g,A1075e,f | K43Rd,g,K121e,f |
Mtb194 | None | None | T70(del),E321e,f,I322Vf,g | R463Lg | D200e,f,D229Gg | None | None | A1075e,f | K121e,f |
Mtb293 | None | None | T70(del),E321e,f,I322Vf,g | C171Gf,g,R463Lg | D200e,f,D229Gg | None | None | A1075e,f | K121e, |
Mtb940 | None | None | T70(del),E321e,f,I322Vf,g | R463Lg | D200e,f,D229Gg | None | None | A1075e,f | K121e,f |
Mtb984 | None | G3 e,f | T70(del),E321e,f,I322Vf,g | S315Td,g,R463Lg | D200e,f,D229Gg | None | F128e,f | L511Pd,g,S512Gg,D516Gg,A1075e,f | K43Rd,g,K121e,f |
Mtb43 | T-8Cd | G3 e,f | T70(del),E321e,f,I322Vf,g | S315Td,g,R463Lg | D200e,f,D229Gg | None | None | S531Ld,g | K43Rd,g,K121e,f |