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Table 2 SNPs and Indels identified in antibiotic resistance-associated regions in M. tuberculosis isolates

From: Comparative genomic analysis of Mycobacterium tuberculosis clinical isolates

  Mutations in target gene or intergenic regions (corresponding drugs)a  
Isolates Rv1483( mabA)b(INH) Rv1484 ( inhA) (INH) Rv1592c (INH) Rv1908c ( katG) (INH) Rv2247 ( accD6) (INH) Rv2428 ( ahpC) (INH) Rv2846c ( efpA) (INH) Rv0667 ( rpoB)c(RMP) Rv0682 ( rpsL) (STR)
Mtb562 None None T70(del),E321e,f,I322Vf,g None None None None A1075e,f None
Mtb526 None None T70(del),E321e,f,I322Vf,g S315Td,g,R463Lg D200e,f,D229Gg S40Nf,g None L511Pd,g,A1075e,f K43Rd,g,K121e,f
Mtb194 None None T70(del),E321e,f,I322Vf,g R463Lg D200e,f,D229Gg None None A1075e,f K121e,f
Mtb293 None None T70(del),E321e,f,I322Vf,g C171Gf,g,R463Lg D200e,f,D229Gg None None A1075e,f K121e,
Mtb940 None None T70(del),E321e,f,I322Vf,g R463Lg D200e,f,D229Gg None None A1075e,f K121e,f
Mtb984 None G3 e,f T70(del),E321e,f,I322Vf,g S315Td,g,R463Lg D200e,f,D229Gg None F128e,f L511Pd,g,S512Gg,D516Gg,A1075e,f K43Rd,g,K121e,f
Mtb43 T-8Cd G3 e,f T70(del),E321e,f,I322Vf,g S315Td,g,R463Lg D200e,f,D229Gg None None S531Ld,g K43Rd,g,K121e,f
  1. a“R”, resistance of isolates to the corresponding anti-TB drug; “S”, sensitivity of isolates to the corresponding anti-TB drug; “del”, deletion; INH, isoniazid; RMP, rifampicin; STR, streptomycin; EMB, ethambutol; PZA, pyrazinamide; OFX, ofloxacin; LVX, levofloxacin; KAN, kanamycin; CAP, capreomycin; AMK, amikacin; ETH, ethionamide.
  2. bintergenic regions.
  3. cnucleotide mutational position is relative to Mycobacterium tuberculosis H37Rv rpoB, and amino acid position is relative to Escherichia coli numbering.
  4. ddrug resistance-asssociated mutations with high confidence.
  5. esynonymous.
  6. fnewly identified mutations.
  7. gnon-synonymous.