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Table 3 SNPs and identified in antibiotic resistance-associated regions in M. tuberculosis isolate s

From: Comparative genomic analysis of Mycobacterium tuberculosis clinical isolates

  Mutations in target gene or intergenic regions (corresponding drugs)a  
Isolates Rv3919c ( gidB) (STR) Rv3793 ( embC) (EMB) Rv3794 ( embA) (EMB) Rv3795 ( embB) (EMB) Rv2043c ( pncA) (PZA) Rv0006 ( gyrA) (OFX, LVX) Rvnr01 ( rrs) (KAN, CAP, AMK) Rv1694 ( tlyA) (KAN, CAP, AMK) Rv3854c ( ethA) (ETH)
Mtb562 S100Fg R927e None None None S95Tg None None Q360Hg
Mtb526 E92Dg,S100Fg,A205e V885Mf,g,R927e C76e None None E21Qg,S95Tg,G668Df,g None L11e Q360Hg
Mtb194 E92Dg,S100Fg,A205e V885Mf,g,R927e C76e None None E21Qg,S95Tg,G668Df,g None L11e Q360Hg
Mtb293 E92Dg,S100Fg,A205e V885Mf,g,R927e C76e None None E21Qg,S95Tg,G668Df,g None L11e Q360Hg
Mtb940 E92Dg,S100Fg,A205e V885Mf,g,R927e C76e None None E21Qg,S95Tg,G668Df,g None L11e Q360Hg
Mtb984 E92Dg,S100Fg,A205e V885Mf,g,R927e G5Sf,g,C76e G406Sd,g F94Sf,g E21Qg,D94Gd,g,S95Tg, G668Df,g None L11e Q360Hg
Mtb43 E92Dg,S100Fg,A205e V885Mf,g C76e M306Vd,g T76Ig E21Qg,D94Gd,g,S95Tg,G668Df,g G1332A,A1401G L11e P164Lf,g,Q360Hg
  1. a“R”, resistance of isolates to the corresponding anti-TB drug; “S”, sensitivity of isolates to the corresponding anti-TB drug; “del”, deletion; INH, isoniazid; RMP, rifampicin; STR, streptomycin; EMB, ethambutol; PZA, pyrazinamide; OFX, ofloxacin; LVX, levofloxacin; KAN, kanamycin; CAP, capreomycin; AMK, amikacin; ETH, ethionamide.
  2. bintergenic regions.
  3. cnucleotide mutational position is relative to Mycobacterium tuberculosis H37Rv rpoB, and amino acid position is relative to Escherichia coli numbering.
  4. ddrug resistance-asssociated mutations with high confidence.
  5. esynonymous.
  6. fnewly identified mutations.
  7. gnon-synonymous.