Figure 2

ASE in F1. A and B depict allelic imbalance (expressed as log2 fold change) versus mean expression, using either parent of origin (A) or strain (B) as the main variable. Genes with significant allelic imbalance (FDR adjusted p-value < 0.05) are in red. Significant cis-eQTLs were identified for 1085 genes (A) while parental imbalance was significant only for 5 genes (B), plots backgrounds are shaded and labeled according to the direction of allelic imbalance. C. Allelic expression of variants resulting in premature stop codons (n = 60, red), or in loss of stop codons (n = 16, black). D. Allelic expression of all known imprinted genes detected in our samples. Gene name color and plot background indicated the expected expressed allele (red = maternal, blue = paternal). Dots and diamonds indicate expression of the maternal and paternal allele, respectively. Red and blue filled shapes indicate genes that show significant allelic imbalance (in red in B), grey filled shapes indicate that the observed difference does not reach 0.05 significance level.