Figure 7
Case study of TBP in the mouse MEL cell-line. (a) TFBS-landscape view for TBP PWM on a TBP dataset. The top plot presents the top scoring motif distance to the peakMax (x-axis) and the motif relative score on the y-axis. The bottom plot presents a histogram of motif distances to the peakMax: black line – 2 bp resolution of the top scoring motif distance per peak; green line – 5 bp resolution of distances for the top scoring motifs with a score equal to or higher than 85. The sequence logo is for TBP. (b) TFBS-landscape view density plots for 15 PWM’s are overlaid on a single plot, for visualization purposes. The black line is the enrichment of the TBP motif, the coloured lines are NR2F1, MYC::MAX, CTCF, GABPA, TAL1::TCF3, FOSL2, FOXD3, NRF1, MEF2A, AP1, SPI1, ZNF143_b, E2F1, and NFYB motifs, as noted on the plot. (c) The Dinucleotide-environment view around the TBP motif. The x-axis is the location of the dinucleotide with respect to the TBP motif, and the y-axis is the fraction of sequences with the dinucleotide at a given position. The coloured lines each represent one of 16 dinucleotides, as specified in the plot legend. The magenta box highlights the dinucleotide enrichment in the regions flanking the TBP motif.