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Table 4 Enrichment of gene groups up-regulated in muscle-less humeri based on GO terms under subontologies biological process and cellular component

From: Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways

Gene ontology: biological process Gene count in study Enrichment1
Adhesion/Extracellular matrix 32 1.99 × 10-10 to 0.0842
  GO:0007155: Cell adhesion 41 1.99E-10
  GO:0022610: Biological adhesion 41 2.12E-10
  GO:0007156: Homophilic cell adhesion 15 4.95 × 10-7
  GO:0016337: Cell-cell adhesion 19 9.38 × 10-6
  GO:0043062: Extracellular structure organization 9 0.0223
  GO:0030198: Extracellular matrix organisation 6 0.0842
Cell signalling 33 3.45 × 10-9 to 0.0148
  GO:0007267: Cell-cell signalling 27 3.45 × 10-9
  GO:0007154: Cell communication 33 2.05 × 10-9
  GO:0007223: Wnt receptor signalling pathway, calcium modulating pathway 7 0.0092
  GO:0016055: Wnt receptor signalling pathway 4 0.0104
  GO:0008589: Regulation of smoothened signalling pathway 9 0.0105
  GO:0010648: Negative regulation of smoothened signalling pathway 4 0.0135
  GO:0048010: Vascular endothelial growth factor receptor signalling pathway 10 0.0288
  GO:0007169: Transmembrane receptor protein tyrosine kinase signalling pathway 3 0.0402
  GO:0007167: Enzyme linked receptor protein signalling pathway 12 0.0051
  GO:0007165: Signal transduction 80 0.0148
Development/Differentiation [34] 4.38 × 10-6 to 0.0083
  GO:0048731: System development 78 4.38 × 10-6
  GO:0048856: Anatomical structure development 81 8.42 × 10-6
  GO:0007275: Multicellular organismal development 87 6.80 × 10-5
  GO:0048468: Cell development 31 8.17 × 10-5
  GO:0032502: Developmental process 91 1.82 × 10-4
  GO:0048869: Cellular developmental process 59 5.41 × 10-4
  GO:0030154: Cell differentiation 57 5.74 × 10-4
  GO:0048513: Organ development 56 0.0036
  GO:0045595: Regulation of cell differentiation 18 0.0083
Gene ontology: cellular component Gene count in study Enrichment 1
Extracellular region 35 2.34 × 10-10 to 0.022
  GO:0005576: Extracellular region 81 2.34 × 10-10
  GO:0044421: Extracellular region part 43 2.70 × 10-7
  GO:0031012: Extracellular matrix 22 1.16 × 10-5
  GO:0005578: Proteinaceous extracellular matrix 21 2.14 × 10-5
  GO:0005615: Extracellular space 24 0.0020
  GO:0044420: Extracellular matrix part 7 0.0202
Membrane association 227 2.46 × 10-16 to 1.01 × 10-6
  GO:0005886: Plasma membrane 134 2.46 × 10-16
  GO:0031224: Intrinsic to membrane 191 1.07 × 10-8
  GO:0044425: Membrane part 215 2.08 × 10-8
  GO:0016020: Membrane 226 7.80 × 10-8
  GO:0031224: Intrinsic to membrane 178 1.01 × 10-6
  1. 1P-value of enrichment of GO terms using DAVID analysis software; similar results were found with GOstat.