Table 4 Enrichment of gene groups up-regulated in muscle-less humeri based on GO terms under subontologies biological process and cellular component

Adhesion/Extracellular matrix

32

1.99 × 10^-10 to 0.0842

  GO:0007155: Cell adhesion

41

1.99E-10

  GO:0022610: Biological adhesion

41

2.12E-10

  GO:0007156: Homophilic cell adhesion

15

4.95 × 10^-7

  GO:0016337: Cell-cell adhesion

19

9.38 × 10^-6

  GO:0043062: Extracellular structure organization

9

0.0223

  GO:0030198: Extracellular matrix organisation

6

0.0842

Cell signalling

33

3.45 × 10^-9 to 0.0148

  GO:0007267: Cell-cell signalling

27

3.45 × 10^-9

  GO:0007154: Cell communication

33

2.05 × 10^-9

  GO:0007223: Wnt receptor signalling pathway, calcium modulating pathway

7

0.0092

  GO:0016055: Wnt receptor signalling pathway

4

0.0104

  GO:0008589: Regulation of smoothened signalling pathway

9

0.0105

  GO:0010648: Negative regulation of smoothened signalling pathway

4

0.0135

  GO:0048010: Vascular endothelial growth factor receptor signalling pathway

10

0.0288

  GO:0007169: Transmembrane receptor protein tyrosine kinase signalling pathway

3

0.0402

  GO:0007167: Enzyme linked receptor protein signalling pathway

12

0.0051

  GO:0007165: Signal transduction

80

0.0148

Development/Differentiation

[34]

4.38 × 10^-6 to 0.0083

  GO:0048731: System development

78

4.38 × 10^-6

  GO:0048856: Anatomical structure development

81

8.42 × 10^-6

  GO:0007275: Multicellular organismal development

87

6.80 × 10^-5

  GO:0048468: Cell development

31

8.17 × 10^-5

  GO:0032502: Developmental process

91

1.82 × 10^-4

  GO:0048869: Cellular developmental process

59

5.41 × 10^-4

  GO:0030154: Cell differentiation

57

5.74 × 10^-4

  GO:0048513: Organ development

56

0.0036

  GO:0045595: Regulation of cell differentiation

18

0.0083

Gene ontology: cellular component

Gene count in study

Enrichment ¹

Extracellular region

35

2.34 × 10^-10 to 0.022

  GO:0005576: Extracellular region

81

2.34 × 10^-10

  GO:0044421: Extracellular region part

43

2.70 × 10^-7

  GO:0031012: Extracellular matrix

22

1.16 × 10^-5

  GO:0005578: Proteinaceous extracellular matrix

21

2.14 × 10^-5

  GO:0005615: Extracellular space

24

0.0020

  GO:0044420: Extracellular matrix part

7

0.0202

Membrane association

227

2.46 × 10^-16 to 1.01 × 10^-6

  GO:0005886: Plasma membrane

134

2.46 × 10^-16

  GO:0031224: Intrinsic to membrane

191

1.07 × 10^-8

  GO:0044425: Membrane part

215

2.08 × 10^-8

  GO:0016020: Membrane

226

7.80 × 10^-8

  GO:0031224: Intrinsic to membrane

178

1.01 × 10^-6