Table 2 Significantly enriched top 20 GeneGo pathways a
Maps | p-value | FDR | Gene/protein symbols |
|---|---|---|---|
SCAP/SREBP Transcriptional Control of Cholesterol and FA Biosynthesis | 6.0E-09 | 0 | HMDH, SREBP1 (Golgi membrane), ACLY, ACSA, SCD5, SREBP1 precursor, SREBP1 (nuclear), ACACA |
Regulation of lipid metabolism_Regulation of lipid metabolism via LXR, NF-Y and SREBP | 2.1E-05 | 0 | SREBP1 (Golgi membrane), ACLY, SREBP1 precursor, SREBP1 (nuclear), ACACA |
Adiponectin in pathogenesis of type 2 diabetes | 1.2E-04 | 0 | SREBP1 precursor, p38alpha (MAPK14), SREBP1 (nuclear), ACACA |
Immune response_Oncostatin M signaling via MAPK in mouse cells | 2.6E-04 | 0 | EGR1, PPAR-gamma, p38 MAPK, c-Fos |
Development_Role of IL-8 in angiogenesis | 2.8E-04 | 0 | HMDH, SREBP1 (Golgi membrane), SREBP1 precursor, SREBP1 (nuclear), c-Fos |
Immune response_Oncostatin M signaling via MAPK in human cells | 3.2E-04 | 0 | EGR1, PPAR-gamma, p38 MAPK, c-Fos |
Development_Gastrin in differentiation of the gastric mucosa | 3.5E-04 | 0 | PKC-beta, EGR1, PKC, cPKC (conventional) |
Development_EGFR signaling pathway | 4.2E-04 | 0 | PKC-beta, p38 MAPK, p38alpha (MAPK14), c-Fos, Bax |
Regulation of lipid metabolism_Regulation of fatty acid synthase activity in hepatocytes | 6.1E-04 | 0 | SREBP1 (Golgi membrane), SREBP1 precursor, SREBP1 (nuclear) |
Regulation of lipid metabolism_Insulin regulation of fatty acid methabolism | 1.2E-03 | 0 | SREBP1 (Golgi membrane), ACLY, SREBP1 precursor, SREBP1 (nuclear), ACACA |
SREBP1 cross-talk with PXR, CAR and LXR | 1.6E-03 | 0 | SREBP1 (Golgi membrane), SREBP1 precursor, SREBP1 (nuclear) |
G-protein signaling_Ras family GTPases in kinase cascades (schema) | 1.6E-03 | 0 | p38 MAPK, p38alpha (MAPK14), c-Fos |
DNA damage_ATM / ATR regulation of G2 / M checkpoint | 1.6E-03 | 0 | BLM, p38alpha (MAPK14), GADD45 beta |
Cell cycle_Transition and termination of DNA replication | 2.0E-03 | 0.1 | PCNA, FEN1, POLD cat (p125) |
Apoptosis and survival_p53-dependent apoptosis | 2.2E-03 | 0.1 | p38alpha (MAPK14), GADD45 beta, Bax |
Renin-Angiotensin-Aldosterone System | 2.3E-03 | 0.1 | PKC-beta, CaMK I, p38alpha (MAPK14), c-Fos |
Neuroprotective action of lithium | 2.4E-03 | 0.1 | p38 MAPK, p38alpha (MAPK14), Dsh, Bax |
SREBP1 cross-talk with PXR, CAR and LXR/ Rodent version | 2.6E-03 | 0.1 | SREBP1 (Golgi), SREBP1 precursor, SREBP1 (nuclear) |
Development_Inhibition of angiogenesis by PEDF | 2.6E-03 | 0.1 | PPAR-gamma, p38 MAPK, Bax |
DNA damage_ATM/ATR regulation of G1/S checkpoint | 2.9E-03 | 0.1 | PCNA, BLM, GADD45 beta |