Table 3 Putative virulence factors present in E. mundtii
Virulence factor | Genes | Homologous locus | Role in pathogenesis | Reference |
|---|---|---|---|---|
Adhesin | ||||
scm | EfaeDRAFT_0418 | Adherence | [41] | |
Pili | ||||
ebpABC | EF1091-EF1093 | Biofilm formation | [42] | |
ebpR | EF1090 | ebp locus regulation | [43] | |
strC | EF0194 | Pilus Sortase C | [42] | |
strA | EF3056 | Pilus Sortase A | [44] | |
rnjB | EF1185 | ebp locus regulation | [45] | |
Capsule | ||||
eps locus | EFSG_00424, −25, −26, −31, −33, −35 to −41 | Resistance to phagocytosis | [16] | |
Cell wall | ||||
galU | EF1746 | Resistance to multiple types of stress | [46] | |
bgsAB | EF2891- EF2890 | Adherence and biofilm formation | [47] | |
dlt locus | EF2749-EF2746 | Biofilm formation | [46] | |
bopD | EF0954 (MalR) | Biofilm formation | [48] | |
epa locus | EFWG_01395-EFWG_01370 | Biofilm and resistance to PMNs | [49] | |
sagA | EfaeDRAFT_1606 | Adherence | [50] | |
Others | ||||
efafm | EfaeDRAFT_2037 | Adherence | [43] | |
msrA | EF1681 | Oxidative stress | [51] | |
msrB | EF3164 | Oxidative stress | [51] | |
gls33 | EfaeDRAFT_2384 | Stress response protein | [52] | |
gls20 | EfaeDRAFT_2389 | Stress response protein | [52] | |
sigV1 and sigV2 | EF3180 | Mouse bacteremia | [53] | |
eep | EF2380 | Biofilm formation | [54] |