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Table 2 Functional clusters over-represented among genes with a significant interaction between maternal undernutrition and postnatal leptin treatment

From: Thrifty metabolic programming in rats is induced by both maternal undernutrition and postnatal leptin treatment, but masked in the presence of both: implications for models of developmental programming

Expression pattern

Annotation group

Genes with AB interaction

Induced by maternal undernutrition and by leptin treatment, but not by both combined (Groups 1 & 3)

Mitochondrially-targeted genes (enrichment score 2.64 → 4.55)

Aadac; Aadat; Abcb11; Acat2; Acsl3; Acsl5; Adhfe1; Agtr1a; Aifm1; Ak3l1; Aldh1b1; Aldh1l2; Atad1; Atp6v1a1; Bche; Bckdhb; Bphl; Cabc1; Clpx; Crls1; Cry1; Cyb5r3; Cyp2r1; Dhcr24; Dhtkd1; Dnaja3; Fam82a; Fut8; Glud1; Gm2a; Golph3; Gpam; Gpd2; Hmbs; Hmgcr; NIT2; LOC501346; LOC685778; LOC688587; TTC19; Lrp5; Lypla1; Maoa; Maob; Me1; Mgst1; Mpv17l; Mrpl18; Mrpl50; Mterfd3; Mtfr1; Nnt; Nsdhl; Otc; Pck2; Pdhb; Qdpr; Rab5a; RGD1308114; RGD1309676; PEX1; MYO6; MUT; TMEM70; Rilp; Rpl10a; Sars2; Scp2; Scrn1; Sec22b; Senp2; Sfxn5; Slc16a1; Slc25a17; Slc35a3; Slc35b3; Sod2; St3gal6; Synj2bp; Tbc1d15; Tm7sf2; Tmpo; Tnks2; Txndc1; Uros

Microsome/peroxisome/cytochrome p450 pathway (enrichment score 2.03 → 4.46)

A1cf; Aadac; Abca6; Abcb11; Acsl3; Acsl5; Agl; Aifm1; Aldh1a1; Baat; Bche; Cabc1; Cadm1; Clcn2; Cnbp; Csnk1g3; Ctsc; Cyb5r3; Cyp2d22; Cyp2d5; Cyp2r1; Dhcr24; Dio1; Dpys; Ephx1; Erap1; Fmr1; Gbe1; Hmgcr; Isoc1; Maoa; Mbl1; Mbl2; Me1; Mgst1; Mpv17l; Nsdhl; Nt5e; Pck2; Pgd; Pgk1; Pipox; Ppp1r3b; Ptprf; Pygl; Rab5a; Rdh3; PEX1; GNPNAT1; Rgs16; Sat1; Scp2; Sec22b; Slc10a1; Slc25a17; Sod2; Sord; Srd5a1; Tm7sf2; Tmco1; Tmed5; Tnks2; Txndc1; Ugt2b; Ugt2b17; Ugt2b36

Steroid synthesis and response (enrichment score 1.86 → 2.69)

Aadac; Abcb11; Abhd5; Acsl3; Acsl5; Afp; Agl; Agtr1a; Ak3l1; Aldh1a1; Angptl4; Avpr1a; Baat; Bche; Bckdhb; Btg1; Cfb; Crls1; Ctsc; Cyb5r3; Cyp2d22; Cyp2r1; Dhcr24; Dnaja3; Dnajb5; Ephx1; Erap1; Foxo1a; Fut8; Gpam; Hmgcr; Ihh; Laptm4b; LOC501346; ANGPTL3; LOC686548; LOC688587; Lrp5; Me1; Mgst1; Mif; Nfe2l2; Nsdhl; Osbp; Pck2; Pggt1b; Prkaa1; Rab5a; Rcan1; RGD1560513; MYO6; STARD5; Scrn1; Sec22b; Senp2; Serpina3m; Serpinf1; Slc34a2; Slc35a3; Smad2; Sord; Srd5a1; St3gal6; Sult1a1; Tm7sf2; Tmpo; Tnks2; Txndc1; Uros

Starch metabolism (enrichment score 3.09)

Adh6; Agl; Aldh1a1; Aldh1b1; Amy1a; Cyp2d22; Cyp2d5; Dpys; Ephx1; Fut8; Gbe1; Hmbs; Maoa; Maob; Mgst1; Pygl; Rdh3; Srd5a1; St3gal6; Ugt2a3; Ugt2b; Ugt2b10; Ugt2b17; Ugt2b36; Uros

Monosaccharide metabolism (enrichment score 2.84)

Adh6; Agl; Aifm1; Aldh1a1; Aldh1b1; Atf4; Atp6v1a1; Bckdhb; Csnk1g3; Cyb5r3; Dhtkd1; Dio1; Dpys; Gbe1; Gm2a; Gpd2; Hmgcr; LOC685778; Maoa; Me1; Pck2; Pdhb; Pgd; Pgk1; Ppp1r3b; Prkaa1; Pygl; UAP1; GNPNAT1; Sat1; Slc16a1; Sod2; Sord

Pyruvate metabolism (enrichment score 2.23)

Acat2; Acot12; Adh6; Aldh1b1; Atf4; Gpd2; LOC685778; Me1; Pck2; Pdhb; Pgk1; Slc16a1

Complement cascade and innate immunity (enrichment score 0.98)

Baat; C2; Cabc1; Cadm1; Cfb; Dhcr24; Dnaja3; Erap1; F9; Ihh; LEAP2; LOC686548; Mbl1; Mbl2; Mif; Mst1; Nrep; RGD1560513; Serpina5; Sod2

Repressed by leptin in UN offspring, induced by leptin in control offspring (Group2)

Metal ion binding (enrichment score 3.00)

Aox1; Arsk; Atp2b1; Cdo1; Cnot6; Cyp2b3; Cyp3a3; Fancl; Gatad2b; Ireb2; ZZZ3; PHF20L1; Mdm4; Msl2l1; Nr5a2; Pcgf4; Pde8a; Phospho2; Prickle1; RGD1563633; Slc10a5; Slc30a7; Slc40a1; Thrb; Tmlhe; Trim33; Upb1; Zfp131; Zfp410; Zfp99

Repressed by maternal undernutrition and by leptin treatment, but not by both combined (Groups 4 & 5)

MHC antigens and lymphocyte activation (enrichment score 2.43 → 4.00)

Ccl5; Ccrl2; Cd69; Cd8a; Coro1a; Ctsl1; Fas; Gpsm3; Gstp1; H2-M3; Icam2; Igh-1a; Il1b; Itgb2; Klrd1; RGD1561628; Msh2; P2ry14; SH2D1A; Rpl9; RT1-149; RT1-A2; RT1-A3; RT1-Ba; RT1-CE15; RT1-CE7; RT1-M6-2; Sart1; Spn; Tap2; Tnfaip8l2; Tnfsf13; Unc13d; Unc93b1; Vcam1; Wdr46; Xcl1

Ribosomal biogenesis/translational elongation (enrichment score 2.27)

Anxa1; Bloc1s2; Cpsf3; Epb4.1 l1; Gtf2b; Hnrpab; RPL22L2; Mrps25; Nufip1; Nup210; Polr2h; Polr2i; Polr2j; Pop4; RGD1559639; RGD1559951; Rnasen; Rpl17; Rpl18a; Rpl9; Rps14; Rps16; Rps17; Rps27; Sart1; Snrp1c; Tdrd3; Tubb5; Utp14a; Uxt; Wdr46

Induced by the combination of maternal undernutrition and leptin treatment, but not by either factor alone (Group 6)

Ribosomal biogenesis/nucleolus (enrichment score 4.87)

Agxt; Cct2; Cdc25a; Cdk105; Colq; Copb1; Dctn6; Epb4.1 l1; Fabp2; Ftl1; Gabarap; Gtf2a2; Gys2; Hnrnpa1; Hspb1; Imp3; Krt10; RPL22L1; LOC364236; RGD1563484; RPS7; RGD1564519; RGD1564606; POLR2E; Mapre3; Med6; Mettl11a; MGC114381; Mrpl49; Myo5b; Myrip; Nbn; Pola2; Psma6; Psma7; Psmb2; Ptk2; Ranbp1; Rassf5; WDR83; RGD1559574; RGD1559846; RGD1561086; RPS19L1; WTAP; RGD1565170; ZCCHC17; RGD1566137; RGD1566326; Rpain; Rpl27; Rpl35a; Rsl1d1; Sfrs2; Sqstm1; Tp53; Tuba4a; Vps33b

Cell cycle/Mitosis (enrichment score 1.70)

Cdc25a; Gadd45gip1; Mapre3; MGC114381; Nbn; Psma6; Psma7; Psmb2; Ranbp1; Rgs10; Tp53; Usp16

  1. Note that individual genes may be annotated within several different functional clusters. Full DAVID output for each of the six groups is given in Additional file 3: Table S3.